G
Gerhard Wagner
Researcher at Harvard University
Publications - 611
Citations - 53772
Gerhard Wagner is an academic researcher from Harvard University. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Protein structure. The author has an hindex of 116, co-authored 589 publications receiving 50309 citations. Previous affiliations of Gerhard Wagner include Howard Hughes Medical Institute & Ben-Gurion University of the Negev.
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Improved spectral resolution in cosy 1H NMR spectra of proteins via double quantum filtering.
TL;DR: The elimination of the dispersive character of the diagonal peaks in phase-sensitive, double quantum-filtered COSY spectra allows identification of cross peaks lying immediately adjacent to the diagonal, which represents a significant improvement over the conventional COSy experiment.
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Identification of RIP1 kinase as a specific cellular target of necrostatins.
Alexei Degterev,Junichi Hitomi,Megan Germscheid,Irene L. Ch’en,Olga Korkina,Xin Teng,Derek W. Abbott,Derek W. Abbott,Gregory D. Cuny,Chengye Yuan,Gerhard Wagner,Stephen M. Hedrick,Scott A. Gerber,Alexey Lugovskoy,Alexey Lugovskoy,Junying Yuan +15 more
TL;DR: Necroptosis is a cellular mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective ligands under conditions where apoptotic execution is prevented and necrostatins are established as the first-in-class inhibitors of RIP1 kinase, the key upstream kinase involved in the activation of necroptosis.
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Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix
Loren D. Walensky,Andrew L. Kung,Andrew L. Kung,Iris Escher,Thomas J. Malia,Thomas J. Malia,Scott Barbuto,Renee D. Wright,Gerhard Wagner,Gregory L. Verdine,Stanley J. Korsmeyer +10 more
TL;DR: Hydrocarbon stapling of native peptides may provide a useful strategy for experimental and therapeutic modulation of protein-protein interactions in many signaling pathways.
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Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
Jason W. Locasale,Alexandra R. Grassian,Tamar Melman,Costas A. Lyssiotis,Katherine R. Mattaini,Adam J. Bass,Adam J. Bass,Gregory J. Heffron,Christian M. Metallo,Taru A. Muranen,Hadar Sharfi,Atsuo T. Sasaki,Dimitrios Anastasiou,Edouard Mullarky,Natalie I. Vokes,Mika Sasaki,Rameen Beroukhim,Rameen Beroukhim,Gregory Stephanopoulos,Azra H. Ligon,Matthew Meyerson,Matthew Meyerson,Andrea L. Richardson,Lynda Chin,Gerhard Wagner,John M. Asara,Joan S. Brugge,Lewis C. Cantley,Matthew G. Vander Heiden,Matthew G. Vander Heiden +29 more
TL;DR: It is found that in some cancer cells a relatively large amount of glycolytic carbon is diverted into serine and glycine metabolism through phosphoglycerate dehydrogenase (PHGDH).
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Solution structure of the integral human membrane protein VDAC-1 in detergent micelles.
Sebastian Hiller,Robert G. Garces,Thomas J. Malia,Vladislav Yu. Orekhov,Vladislav Yu. Orekhov,Marco Colombini,Gerhard Wagner +6 more
TL;DR: NMR measurements revealed the binding sites of VDAC-1 for the BCl-2 protein Bcl-xL, for reduced β–nicotinamide adenine dinucleotide, and for cholesterol as well as voltage-gated channels in phospholipid bilayers similar to those of the native protein.