J
Julie C. Mcmanus
Researcher at AstraZeneca
Publications - 4
Citations - 133
Julie C. Mcmanus is an academic researcher from AstraZeneca. The author has contributed to research in topics: Suzuki reaction & Carboxylic acid. The author has an hindex of 3, co-authored 4 publications receiving 129 citations.
Papers
More filters
Journal ArticleDOI
Multikilogram-Scale Synthesis of a Biphenyl Carboxylic Acid Derivative Using a Pd/C-Mediated Suzuki Coupling Approach
David S. Ennis,Julie C. Mcmanus,‡ Wladyslaw Wood-Kaczmar,John Edward Richardson,and Gillian E. Smith,Alexis Carstairs +5 more
TL;DR: In this article, NaOH is added to a mixture of 4-bromo-3-methylaniline, 4-chlorobutyryl chloride, and catalytic TBAC in THF/H2O.
Journal ArticleDOI
Successful Development and Scale-up of a Palladium-Catalysed Amination Process in the Manufacture of ZM549865
Graham E. Robinson,Oliver R. Cunningham,Mouloud Dekhane,Julie C. Mcmanus,Anne O’Kearney-McMullan,Abdurrazzaque M. Mirajkar,Vikas Mishra,Alison Norton,B. Venugopalan,Emyr G. Williams +9 more
TL;DR: In this article, the palladium-catalysed amination of ethyl 8-bromo-6-fluoro-4-oxo-4H-2-chromenecarboxylate and subsequent hydrolysis of the ester group is described.