Journal ArticleDOI
Multikilogram-Scale Synthesis of a Biphenyl Carboxylic Acid Derivative Using a Pd/C-Mediated Suzuki Coupling Approach
David S. Ennis,Julie C. Mcmanus,‡ Wladyslaw Wood-Kaczmar,John Edward Richardson,and Gillian E. Smith,Alexis Carstairs +5 more
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In this article, NaOH is added to a mixture of 4-bromo-3-methylaniline, 4-chlorobutyryl chloride, and catalytic TBAC in THF/H2O.About:
This article is published in Organic Process Research & Development.The article was published on 1999-05-21. It has received 110 citations till now. The article focuses on the topics: Yield (chemistry) & Suzuki reaction.read more
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Organic Reactions in Aqueous Media with a Focus on Carbon−Carbon Bond Formations: A Decade Update
TL;DR: Reaction of R,â-Unsaturated Carbonyl Compounds 3127: Reaction of R-UnSaturated Carbonies 3127 7.1.6.
Journal ArticleDOI
Carbon-Carbon Coupling Reactions Catalyzed by Heterogeneous Palladium Catalysts
Lunxiang Yin,Jürgen Liebscher +1 more
TL;DR: Pd on Modified Silica 159 4.5.1.
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Selected patented cross-coupling reaction technologies.
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Large-scale applications of transition metal-catalyzed couplings for the synthesis of pharmaceuticals.
Javier Magano,Joshua R. Dunetz +1 more
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Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals
TL;DR: In this article, a review of coupling reagents for large-scale amide synthesis via the condensation of an acid and amine is presented, highlighting the benefits and drawbacks of each reagent on an industrial scale.
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Journal ArticleDOI
The Palladium-Catalyzed Cross-Coupling Reaction of Phenylboronic Acid with Haloarenes in the Presence of Bases
TL;DR: The transition metal-catalyzed reactions of organometallics with organic halides have been extensively studied to prove a new approach to selective formation of carbon-carbon bonds as mentioned in this paper.
Journal ArticleDOI
New synthetic transformations via organoboron compounds
TL;DR: In this paper, the palladium-catalyzed cross-coupling reaction of 1-alkenylboron compounds with various vinylic or aryl halides in the presence of base provides the corresponding coupling products.
Journal ArticleDOI
Highly Efficient and Accelerated Suzuki Aryl Couplings Mediated by Phosphine-Free Palladium Sources
Thomas I. Wallow,Bruce M. Novak +1 more
TL;DR: The phosphine-free methodology appears to be generally applicable; cross-couplings of aryl iodides yielding biaryls 6 and 7 proceed without noticeable steric or electronic effects.
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Aryl couplings with heterogeneous palladium catalysts
TL;DR: The coupling reaction of diverse phenylboronic acids with aryl halogenides and triflates has been performed by the use of simple palladium hydrogenation catalysts as discussed by the authors.
Related Papers (5)
Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more