J
Julio A. Copello
Researcher at Loyola University Chicago
Publications - 6
Citations - 1228
Julio A. Copello is an academic researcher from Loyola University Chicago. The author has contributed to research in topics: Ryanodine receptor & Endoplasmic reticulum. The author has an hindex of 4, co-authored 5 publications receiving 1182 citations.
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Journal ArticleDOI
Ryanodine Receptor Calcium Release Channels
Michael Fill,Julio A. Copello +1 more
TL;DR: Controversies surrounding the complex Ca2+ regulation of single RyR channels receive particular attention here and a large body of information is synthesized into a focused perspective of singleRyR channel function.
Journal ArticleDOI
Effects of cytosolic NADH/NAD+ levels on sarcoplasmic reticulum Ca2+ release in permeabilized rat ventricular myocytes
TL;DR: An increase of the cytoplasmic NADH/NAD+ ratio depresses SR Ca2+ release in ventricular cardiomyocytes and appears to be mediated by direct NADH inhibited of RyR channel activity and by indirect NADH inhibition (O2−· mediated) of SR Ca 2+‐ATPase activity with a subsequent decrease in SRCa2+ content.
Journal ArticleDOI
Differential modulation of cardiac and skeletal muscle ryanodine receptors by NADH
TL;DR: The results suggest that the direct effect of cytosolic NADH is physiologically important for the modulation of cardiac RyRs and interactions with the ATP binding site(s) of the channels.
Journal ArticleDOI
Differential Ca2+ and Sr2+ regulation of intracellular divalent cations release in ventricular myocytes
Maria E. Zoghbi,Julio A. Copello,Carlos A. Villalba-Galea,P. Vélez,P. L. Diaz Sylvester,Pura Bolaños,Aristides Marcano,Michael Fill,Ariel L. Escobar +8 more
TL;DR: The results suggest that regulation of the RyR channel by cytosolic Ca2+ is not involved in turning off the Ca2- spark, and suggests that the kinetics of local and global RyR-mediated Ca 2+ release signals are affected in a distinct way by different divalent cations in cardiac muscle cells.