Jun Deguchi

TL;DR: Three new alkaloids, cassiarins C-E (1-3), and a new chromone, 10,11-dihydroanhydrobarakol (4), which showed moderate antiplasmodial activity against Plasmodium falciparum 3D7 were isolated from flowers of Cassia siamea, and the structures of 1-4 were elucidated by 2D NMR analysis and chemical transformation.

TL;DR: The results suggest that the vasorelaxant effect of FR900359 is mediated through the increased release of NO from endothelium-intact aortic cells at low concentrations, and can be attributed to inhibitory effects on voltage-dependent Ca2+ channel- and receptor-operated Ca2- channel-dependentCa2+ influx at high concentrations.

TL;DR: Two new cassane-type diterpenes, sucutiniranes A and B, have been isolated from the seeds of Bowdichia nitida together with 6alpha-acetoxyvouacapane and showed in vitro antiplasmodial activity against parasite Plasmodium falciparum 3D7.

TL;DR: Structural-activity relationship of acerogenin derivatives on inhibitory activity of SGLT as well as conformational analysis of 1 and 2 on the basis of J-resolved HMBC spectra and X-ray analysis were discussed.

TL;DR: A series of a hydroxyl and a nitrogen-substituted derivatives and a dehydroxy derivative of 1 have been synthesized as having potent antimalarials against P. falciparum with vasodilator activity, which may reduce cytoadherence of pRBC to vascular endothelium.