T
Takayuki Matsumoto
Researcher at Hoshi University
Publications - 186
Citations - 4863
Takayuki Matsumoto is an academic researcher from Hoshi University. The author has contributed to research in topics: Mesenteric arteries & Endothelium. The author has an hindex of 36, co-authored 176 publications receiving 4428 citations. Previous affiliations of Takayuki Matsumoto include Georgia Regents University.
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Role of Lysophosphatidylcholine (LPC) in Atherosclerosis
TL;DR: The entirety of the signal-transduction system for LPC, its pathophysiological implications, and the vascular abnormalities associated with it are focused on.
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Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats
Cameron G. McCarthy,Camilla F Wenceslau,Styliani Goulopoulou,Safia Ogbi,Babak Baban,Jennifer C. Sullivan,Takayuki Matsumoto,R. Clinton Webb +7 more
TL;DR: Circulating mtDNA and impaired deoxyribonuclease activity may lead to the activation of the innate immune system, via TLR9, and contribute to elevated arterial pressure and vascular dysfunction in SHR.
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Toll-like receptors and damage-associated molecular patterns: novel links between inflammation and hypertension.
Cameron G. McCarthy,Styliani Goulopoulou,Camilla F Wenceslau,Kathryn M. Spitler,Takayuki Matsumoto,R. Clinton Webb +5 more
TL;DR: The role of Toll-like receptor activation on somatic cells of the vasculature in response to the release of DAMPs and the consequences of this activation on inflammation, vasoreactivity, and vascular remodeling will be specifically discussed.
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Impairment of PI3-K/Akt Pathway Underlies Attenuated Endothelial Function in Aorta of Type 2 Diabetic Mouse Model
TL;DR: The results suggest that relaxation responses and NO production mediated via the PI3-K/Akt pathway are decreased in this type 2 diabetic model, which may be a major cause of endothelial dysfunction (and the resulting hypertension) in type 2 diabetes.
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Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes
TL;DR: The results suggest that metformin improves endothelial functions in OLETF mesenteric arteries by suppressing vasoconstrictor prostanoids and by reducing oxidative stress within the timescale studied here.