Jun-Han Su

TL;DR: A super-resolution chromatin tracing method that allows determination of both the structural features and their genomic coordinates with high resolution in single cells is reported, suggesting that cohesin is not required for the formation or maintenance of single-cell domain structures, but that their preferential boundary positions are influenced by cohes in-CTCF interaction.

TL;DR: An imaging method for mapping the spatial positions of numerous genomic regions along individual chromosomes is developed and it is observed that chromosome folding deviates from the ideal fractal-globule model at large length scales and that TADs are largely organized into two compartments spatially arranged in a polarized manner in individual chromosomes.

TL;DR: This work reports an imaging technology for visualizing chromatin organization across multiple scales in single cells with high genomic throughput and envisions broad application of this high-throughput, multi-scale, and multi-modal imaging technology, which provides an integrated view of chromatin organizations in its native structural and functional context.

TL;DR: In this article, the authors outline the essential coronavirus biological characteristics that are important for vaccine design and summarize key takeaways from previous vaccination studies of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), highlighting the pros and cons of each immunization strategy.

TL;DR: This work reports the development of an alternative two-color CRISPR labeling method using only the well-characterized Streptococcus pyogenes Cas9, by incorporating MS2 or PP7 RNA aptamers into the sgRNA.