Jun Hee Lim

TL;DR: It is demonstrated that subtoxic concentrations of curcumin sensitize human renal cancer cells to the tumor necrosis factor-related apoptosis inducing ligand (TRAIL-mediated apoptosis) by ROS-mediated DR5 upregulation.

TL;DR: Monensin effectively sensitizes various glioma cells, but not normal astrocytes, to TRAIL-mediated apoptosis; this occurs at least partly via monensin-induced endoplasmic reticulum (ER) stress, CHOP-mediated DR5 upregulation and proteasome-mediated downregulation of c-FLIP.

TL;DR: Treatment of HT29 human colon carcinoma cells with resveratrol was found to induce a number of signature ER stress markers, and the inhibition of caspase-4 activity by z-LEVD-fmk significantly reduced resver atrol-induced apoptosis, providing strong evidence to support an important role of ER stress response in mediating the resverAtrol- induced apoptosis.

TL;DR: A series of studies designed to understand the genomic structure of BUB3, particularly as it relates to regulation of gene expression are described, indicating that this region 5' region contains distinctive positive and negative regulatory elements.

TL;DR: The release experiments from nocodazole-induced mitotic phase cells indicated that MG132 inhibits the proliferation of HCT116 cells via arrest in the G2 phase, suggesting that p53 and p21 may not be essential for MG132-induced G2/M phase arrest.