J
Jun-Ming Zhang
Researcher at University of Cincinnati Academic Health Center
Publications - 100
Citations - 6861
Jun-Ming Zhang is an academic researcher from University of Cincinnati Academic Health Center. The author has contributed to research in topics: Dorsal root ganglion & Neuropathic pain. The author has an hindex of 38, co-authored 100 publications receiving 5821 citations. Previous affiliations of Jun-Ming Zhang include Elsevier & University of Arkansas for Medical Sciences.
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Journal ArticleDOI
Cytokines, inflammation, and pain.
Jun-Ming Zhang,Jianxiong An +1 more
TL;DR: There is significant evidence showing that certain cytokines/chemokines are involved in not only the initiation but also the persistence of pathologic pain by directly activating nociceptive sensory neurons.
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Mechanical and Thermal Hyperalgesia and Ectopic Neuronal Discharge After Chronic Compression of Dorsal Root Ganglia
TL;DR: It is hypothesize that a chronic compression of the dorsal root ganglion after certain injuries or diseases of the spine may produce, in neurons with intact axons, abnormal ectopic discharges that originate from the ganglions and potentially contribute to low back pain, sciatica, hyperalgesia, and tactile allodynia.
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Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat
TL;DR: After a chronic nerve constriction the DRG becomes a source of abnormal activity modulated by sympathetically released norepinephrine acting on alpha 2 receptors in DRG somata, which may contribute to cutaneous pain and hyperalgesia.
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Enhanced Excitability of Sensory Neurons in Rats With Cutaneous Hyperalgesia Produced by Chronic Compression of the Dorsal Root Ganglion
TL;DR: The association of cutaneous hyperalgesia with changes in the electrophysiological properties ofDRG cells suggests a possible role for intrinsic alterations in the membrane properties of compressed DRG cells in the production and persistence of chronic pain after certain spinal injuries or pathologies of the spine.
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Neuropathic pain: Early spontaneous afferent activity is the trigger
TL;DR: The results indicate that early spontaneous afferent fiber activity is the key trigger for the development of pain behaviors, and suggest that spontaneous activity may be required for many of the later changes in the sensory neurons, spinal cord, and brain observed in neuropathic pain models.