J
Jun Ogasawara
Researcher at Osaka Bioscience Institute
Publications - 11
Citations - 3144
Jun Ogasawara is an academic researcher from Osaka Bioscience Institute. The author has contributed to research in topics: Apoptosis & Fas receptor. The author has an hindex of 10, co-authored 10 publications receiving 3122 citations.
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Journal ArticleDOI
Lethal effect of the anti-Fas antibody in mice
Jun Ogasawara,Rie Watanabe-Fukunaga,Masashi Adachi,Akio Matsuzawa,Tsutomu Kasugai,Yukihiko Kitamura,Naoto Itoh,Takashi Suda,Shigekazu Nagata +8 more
TL;DR: The findings suggest that the Fas antigen is important in programmed cell death in the liver, and may be involved in fulminant hepatitis in some cases.
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Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver.
Masashi Adachi,Sachiko Suematsu,Toru Kondo,Jun Ogasawara,Takashi Tanaka,Nobuaki Yoshida,Shigekazu Nagata +6 more
TL;DR: The Fas system seems to play a role in the apoptotic process to maintain homeostasis of the liver as well as the peripheral lymphoid organs.
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Enhanced and accelerated lymphoproliferation in Fas-null mice
Masashi Adachi,Sachiko Suematsu,Takashi Suda,Daisuke Watanabe,Hidehiro Fukuyama,Jun Ogasawara,Takashi Tanaka,Nobuaki Yoshida,Shigekazu Nagata +8 more
TL;DR: Thymic clonal deletion, assessed by deletion of T cells reactive to mouse endogenous superantigens, was apparently normal in the Fas-/- mice, whereas the peripheral clonal delete of mature T cells against a bacterial superantigen was impaired.
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Fas-mediated apoptosis in primary cultured mouse hepatocytes.
Runzhou Ni,Yumiko Tomita,Koichi Matsuda,Akira Ichihara,Kazunori Ishimura,Jun Ogasawara,Shigekazu Nagata +6 more
TL;DR: It is suggested that cultured mouse hepatocytes express protective proteins against apoptosis and that phosphorylation by PKC is also involved in protection of the hepatocytes from Fas-mediated apoptosis.
Journal ArticleDOI
Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody.
TL;DR: The Fas-induced apoptosis of thymocytes was enhanced by metabolic inhibitors such as cycloheximide and intraperitoneal administration of the anti-Fas antibody into mice caused rapid apoptosis in vivo.