Sensitive optical biosensors for unlabeled targets: a review.

Robotic medical instrument systems and associated methods utilizing an optical fiber sensors such as Bragg sensor optical fibers. In one configuration, an optical fiber is coupled to an elongate instrument body and includes a fiber core having one or more Bragg gratings. A controller is configured to initiate various actions in response thereto. For example, a controller may generate and display a graphical representation of the instrument body and depict one or more position and/or orientation variables thereof, or adjust motors of an instrument driver to reposition the catheter or another instrument. Optical fibers having Bragg gratings may also be utilized with other system components including a plurality of working instruments that are positioned within a sheath lumen, an instrument driver, localization sensors, and/or an image capture device, and may also be coupled to a patient's body or associated structure that stabilizes the body.

Robotic instrument systems and methods utilizing optical fiber sensors

Fiber optic interferometers to sense various physical parameters including temperature, strain, pressure, and refractive index have been widely investigated. They can be categorized into four types: Fabry-Perot, Mach-Zehnder, Michelson, and Sagnac. In this paper, each type of interferometric sensor is reviewed in terms of operating principles, fabrication methods, and application fields. Some specific examples of recently reported interferometeric sensor technologies are presented in detail to show their large potential in practical applications. Some of the simple to fabricate but exceedingly effective Fabry-Perot interferometers, implemented in both extrinsic and intrinsic structures, are discussed. Also, a wide variety of Mach-Zehnder and Michelson interferometric sensors based on photonic crystal fibers are introduced along with their remarkable sensing performances. Finally, the simultaneous multi-parameter sensing capability of a pair of long period fiber grating (LPG) is presented in two types of structures; one is the Mach-Zehnder interferometer formed in a double cladding fiber and the other is the highly sensitive Sagnac interferometer cascaded with an LPG pair.

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Interferometric Fiber Optic Sensors

We report a miniaturized fiber inline Fabry-Perot interferometer (FPI), with an open micro-notch cavity fabricated by one-step fs laser micromachining, for highly sensitive refractive index measurement. The device was tested for measurement of the refractive indices of various liquids including isopropanol, acetone and methanol at room temperature, as well as the temperature-dependent refractive index of deionized water from 3 to 90 degrees C. The sensitivity for measurement of refractive index change of water was 1163 nm/RIU at the wavelength of 1550 nm. The temperature cross-sensitivity of the device was about 1.1x10(-6) RIU/degrees C. The small size, all-fiber structure, small temperature dependence, linear response and high sensitivity, make the device attractive for chemical and biological sensing.

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Temperature-insensitive miniaturized fiber inline Fabry-Perot interferometer for highly sensitive refractive index measurement

We propose and demonstrate a Fabry-Perot (F-P) optical fiber tip sensor for high-resolution refractive-index measurement fabricated by using 157-nm laser micromachining, for the first time to our knowledge. The sensor head consists of a short air F-P cavity near the tip of a single-mode fiber and the fiber tip. The external refractive index is determined according to the maximum fringe contrast of the interference fringes in the reflective spectrum of the sensor. Such a sensor can provide temperature-independent measurement of practically any refractive index larger than that of air and offers a refractive-index resolution of ~4 x 10(-5) in its linear operating range. The experimental data agree well with the theoretical results.

Laser-micromachined Fabry-Perot optical fiber tip sensor for high-resolution temperature-independent measurement of refractive index.

An all-fused-silica pressure sensor fabricated directly onto a fiber tip of 125 μm diameter is described. Simple fabrication steps include only cleaving and fusion splicing. Because no chemical processes are involved, the fabrication is easy, safe, and cost effective. Issues in sensor design and loss analysis are discussed. The sensor has been tested for static pressure response, showing a sensitivity of 2.2 nm/psi, a resolution of 0.01 psi (68.9 Pa), a hysteresis of 0.025%, and capability of operation at temperatures up to 600°C. This miniature sensor may be suitable for medical diagnostics, environmental monitoring, and other industrial applications.

All-fused-silica miniature optical fiber tip pressure sensor

White light interferometry has been used in the sensing area for many years. A novel data processing method for demodulating the information from the interference spectrum of a white light system is presented. Compared with traditional algorithms, both high-resolution and large dynamic range have been achieved with a relatively low-cost system. Details of this arithmetic are discussed. A compact white light interferometric system employing this algorithm has been developed, combined with fiber Fabry-Perot sensors. A60.5-nm stability over 48 hours with a dynamic range on the order of tens of microns has been achieved with this system. The temperature dependence of this system has been analyzed, and a self-compensating data processing approach is adopted. Experimental results demonstrated a 61.5-nm shift in the temperature range of 10 to 45°C. © 2003 Society of Photo-Optical Instrumentation Engineers. (DOI: 10.1117/1.1613958)

Novel data processing techniques for dispersive white light interferometer

A novel diaphragm-based miniature optical fiber pressure sensor has been shown to work at temperatures up to 700/spl deg/C with a sensitivity of 2.93 nm/psi and a resolution of 0.01 psi (68.9 Pa). A passive temperature compensation scheme was used to reduce the temperature dependence to 0.0076 psi//spl deg/C (52.4 Pa//spl deg/C). The sensor exhibited a linear response in the available testing range from 0 to 200 psi (1.38 MPa), and being composed entirely of fused silica, the sensor's structure is very reliable, corrosion resistant, and immune to electromagnetic interference.

A novel temperature-insensitive optical fiber pressure sensor for harsh environments

A fiber optic sensor has a hollow tube bonded to the endface of an optical fiber, and a diaphragm bonded to the hollow tube. The fiber endface and diaphragm comprise an etalon cavity. The length of the etalon cavity changes when applied pressure or acceleration flexes the diaphragm. The entire structure can be made of fused silica. The fiber, tube, and diaphragm can be bonded with a fusion splice. The present sensor is particularly well suited for measuring pressure or acceleration in high temperature, high pressure and corrosive environments (e.g., oil well downholes and jet engines). The present sensors are also suitable for use in biological and medical applications.

Optical fiber pressure and acceleration sensor fabricated on a fiber endface

Detailed studies on fiber optic pressure and temperature sensors for oil down-hole applications are described in this paper. The sensor head is an interferometric based fiber optic senor in which the air-gap will change with the pressure or temperature. For high-speed applications, a novel self-calibrating interferometric/intensity-based (SCIIB) scheme, which realizes compensations for both the light source drift and the fiber loss variation, was used to demodulate the pressure (or temperature) signals. An improved white light system was developed for sensor fabrication. This system is also used as the signal demodulation system providing very high resolution. Experiment results show that the SCIIB system achieves 0.1% accuracy with a 0-8000psi working range for the pressure sensor and a 0-600 degree(s)C working range for the temperature sensor. The resolution of the white light system is about +/- 0.5 nm with a dynamic range up to 10 micrometers. The long -term testing results in the oil site are also presented in this paper.© (2002) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.

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Juncheng Xu

Papers

All-fused-silica miniature optical fiber tip pressure sensor

Novel data processing techniques for dispersive white light interferometer

A novel temperature-insensitive optical fiber pressure sensor for harsh environments

Optical fiber pressure and acceleration sensor fabricated on a fiber endface

Fiber optic pressure and temperature sensors for oil down hole application