Jungchan Park

TL;DR: The combination of PGA and LT produced a greater degree of degradation of mitogen-activated protein kinase kinases and an increased level of the activation of the proform of caspase-1 to its processed form compared to the effects of LT alone.

TL;DR: Many of them including propionyl, cyclopentanoyl and p-nitrobenzoyl-4-(1-hydroxyhexadec-2-enyl)-oxazolidin- 2-ones showed better antileukemic activities than natural C2-ceramide with good correlation between cell death and DNA fragmentation.

TL;DR: It is demonstrated that VarS is also involved in the expression of the virulence proteins CT and Tcp from the V. cholerae classical and El Tor strains through regulation of ToxT expression in response to environmental changes due to different toxin-inducing conditions.

TL;DR: In this paper, the authors reported that polyγ-d-glutamic acid (PGA) conjugates induce expressions of anti-PA, anti-PGA and toxin neutralizing antibodies in guinea-pigs and completely protect guinea pigs against a 50 × LD50 challenge with fully virulent Bacillus anthracis spores.

TL;DR: The results demonstrate that B. anthracis PGA elicits IL-1β production through activation of ICE in PMA-differentiated THP-1 cells and hMoDCs, suggesting the potential for PGA as a therapeutic target for anthrax.