J
Junjun Yang
Researcher at Third Military Medical University
Publications - 16
Citations - 418
Junjun Yang is an academic researcher from Third Military Medical University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 4, co-authored 8 publications receiving 179 citations.
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Journal ArticleDOI
miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis.
Jiangyi Wu,Liang Kuang,Cheng Chen,Junjun Yang,Wei-Nan Zeng,Tao Li,Hao Chen,Shu Huang,Zhenlan Fu,Jiamiao Li,Renfeng Liu,Zhenhong Ni,Lin Chen,Liu Yang +13 more
TL;DR: MSCIPFP-derived exosomes protect articular cartilage from damage and ameliorate gait abnormality in OA mice by maintaining cartilage homeostasis, the mechanism of which may be related to miR100-5p-regulated inhibition of mTOR-autophagy pathway.
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Natural ingredients-derived antioxidants attenuate H2O2-induced oxidative stress and have chondroprotective effects on human osteoarthritic chondrocytes via Keap1/Nrf2 pathway.
Junjun Yang,Xiongbo Song,Yong Feng,Na Liu,Zhenlan Fu,Jiangyi Wu,Tao Li,Hao Chen,Jiajia Chen,Cheng Chen,Liu Yang +10 more
TL;DR: Investigation of the effects of allicin, sulforaphane, and lycopene on H2O2-stimulated human osteochondral samples and osteoarthritic chondrocytes revealed that these antioxidants effectively reduced the oxidative stress-induced cell apoptosis, and increased gene expression of antioxidant enzymes.
Journal Article
Intra-articular injection of etoricoxib-loaded PLGA-PEG-PLGA triblock copolymeric nanoparticles attenuates osteoarthritis progression.
TL;DR: It is found that etoricoxib not only inhibited the expression of inflammation mediators COX-2, prostaglandin E2 (PGE2), and nitric oxide, but also had a similar chondro-protective effect to celecoxib through down-regulating matrix degrading enzymes matrix metalloproteinase-13 (MMP-13).
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Asiatic acid attenuates hypertrophic and fibrotic differentiation of articular chondrocytes via AMPK/PI3K/AKT signaling pathway
Na Liu,Na Liu,Dejie Fu,Junjun Yang,Pingju Liu,Xiongbo Song,Xin Wang,Rui Li,Zhenlan Fu,Jiajia Chen,Xiaoyuan Gong,Cheng Chen,Liu Yang +12 more
TL;DR: Asiatic acid treatment could reduce hypertrophic and fibrotic differentiation and maintain the chondrogenic phenotype of articular chondrocytes by targeting the AMPK/PI3K/AKT signaling pathway.
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Intra-articular injection of anti-inflammatory peptide-loaded glycol chitosan/fucoidan nanogels to inhibit inflammation and attenuate osteoarthritis progression.
Tao Li,Junjun Yang,Changmei Weng,Pingju Liu,Yang Huang,Shuo Meng,Rong Li,Liu Yang,Cheng Chen,Xiaoyuan Gong +9 more
TL;DR: Glycol chitosan/fucoidan nanogels loaded with anti-inflammatory peptide KAFAK (GC/Fu@KAFAK NGs) were fabricated based on the electrostatic interaction and genipin cross-linking methods as mentioned in this paper.