J
Jiangyi Wu
Researcher at Third Military Medical University
Publications - 7
Citations - 465
Jiangyi Wu is an academic researcher from Third Military Medical University. The author has contributed to research in topics: Internal medicine & Osteoarthritis. The author has an hindex of 4, co-authored 4 publications receiving 215 citations.
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miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis.
Jiangyi Wu,Liang Kuang,Cheng Chen,Junjun Yang,Wei-Nan Zeng,Tao Li,Hao Chen,Shu Huang,Zhenlan Fu,Jiamiao Li,Renfeng Liu,Zhenhong Ni,Lin Chen,Liu Yang +13 more
TL;DR: MSCIPFP-derived exosomes protect articular cartilage from damage and ameliorate gait abnormality in OA mice by maintaining cartilage homeostasis, the mechanism of which may be related to miR100-5p-regulated inhibition of mTOR-autophagy pathway.
Journal ArticleDOI
The exosome-like vesicles from osteoarthritic chondrocyte enhanced mature IL-1β production of macrophages and aggravated synovitis in osteoarthritis
Zhenhong Ni,Liang Kuang,Hangang Chen,Yangli Xie,Bin Zhang,Junjie Ouyang,Jiangyi Wu,Siru Zhou,Liang Chen,Nan Su,Qiaoyan Tan,Xiaoqing Luo,Bo Chen,Shuai Chen,Liangjun Yin,Haiyang Huang,Xiaolan Du,Lin Chen +17 more
TL;DR: This study found that the exosome-like vesicles from osteoarthritic chondrocytes could be a new biological factor to stimulate inflammasome activation and increase mature IL-1β production in macrophages.
Journal ArticleDOI
Enzymatically crosslinked and mechanically tunable silk fibroin/pullulan hydrogels for mesenchymal stem cells delivery.
Tao Li,Xiongbo Song,Changmei Weng,Xin Wang,Jiangyi Wu,Li Sun,Xiaoyuan Gong,Wei-Nan Zeng,Liu Yang,Cheng Chen +9 more
TL;DR: These features support that SF/PL hydrogels have a potential as cell delivery scaffold in musculoskeletal tissue engineering.
Journal ArticleDOI
FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice.
Liang Kuang,Jiangyi Wu,Nan Su,Huabing Qi,Hangang Chen,Siru Zhou,Yan Xiong,Xiaolan Du,Qiaoyan Tan,Jing Yang,Min Jin,Fengtao Luo,Junjie Ouyang,Bin Zhang,Zuqiang Wang,Wanling Jiang,Liang Chen,Shuai Chen,Ziming Wang,Peng Liu,Liangjun Yin,Feng-Jin Guo,Chu-Xia Deng,Di Chen,Chuan-ju Liu,Yangli Xie,Zhenhong Ni,Lin Chen +27 more
TL;DR: The role of FGFR3 is identified in synovial macrophage recruitment and synovitis, which provides a new insight into the pathological mechanisms of inflammation-related arthritis.
Journal ArticleDOI
Autophagy in the pathogenesis and therapeutic potential of post-traumatic osteoarthritis
Yunquan Gong,Song Li,Jinghui Wu,Tongyi Zhang,Shunzheng Fang,Daibo Feng,Xiaoqing Luo,Jing Yuan,Yaran Wu,Xiaojing Yan,Yan Zhang,Jun Zhu,Jiangyi Wu,Jiqin Lian,Wei Xiang,Zhenhong Ni +15 more
TL;DR: In this paper , the authors summarized the roles and mechanisms of autophagy in post-traumatic OA and the current strategies for PTOA treatment that depend on autoophagy regulation.