Junmei Wang

TL;DR: The results appear to indicate that pharmacodynamics may play a more important role than PKs in causing DDIs between opioids and benzodiazepines, and that molecular modeling can be a very useful tool to mitigate the problem of “missing metabolic reaction parameters” in PK modeling and simulation.

TL;DR: MscL activators have potential as novel broad‐spectrum antibiotics or adjuvants that work with antibiotics to selectively allow passage across bacterial membranes and can increase potency of other antibiotics, presumably by permeabilizing the membrane and allowing easier access of the antibiotic into the cytoplasm.

TL;DR: This is the first study to provide a landscape view of DR-associated mutation hotspots in kinase's secondary structures, and its knowledge will help the development of effective next-generation KIs for better precision medicine.

TL;DR: A joint mid-infrared free electron laser experiment/non-equilibrium molecular dynamics simulation to understand the dissociation process of a representative example GNNQQNY fibril finds that dissociation starts in the core of the fibrils by fragmenting the intermolecular hydrogen bonds and separating the peptides and then propagates to thefibril extremities leading to the formation of unstructured expanded oligomers.

TL;DR: This work carried out a series of molecular docking studies between paracetamol/AM404/NAQPI and their reported targets, including CYP 2E1, FAAH, TRPA1, CB1, and TRPV1 for further investigation of the dynamics interactions, and summarized and discussed the reported drug–drug interactions between par acetamol and central nervous system drugs, especially illicit drugs.