Phuong H. Nguyen

TL;DR: Simulations Complement Experimental Studies Jessica Nasica-Labouze, Phuong H. Nguyen, Fabio Sterpone,† Olivia Berthoumieu,‡ Nicolae-Viorel Buchete, Sebastien Cote, Alfonso De Simone, Andrew J. Doig, and Philippe Derreumaux are authors of this paper.

TL;DR: It is shown that the dPCA amounts to a one-to-one representation of the original angle distribution and that its principal components can readily be characterized by the corresponding conformational changes of the peptide.

TL;DR: In this paper, the authors review what computer, in vitro, in vivo, and pharmacological experiments tell us about the accumulation and deposition of the oligomers of the (Aβ, tau), α-synuclein, IAPP, and superoxide dismutase 1 proteins, which have been the mainstream concept underlying Alzheimer's disease, Parkinson's disease (PD), type II diabetes (T2D), and amyotrophic lateral sclerosis (ALS) research.

TL;DR: Energy transport through an α-aminoisobutyric acid-based 310-helix dissolved in chloroform is investigated in a combined experimental-theoretical approach, revealing good qualitative agreement with experiment but in terms of quantitative numbers, theory and experiment differ.

TL;DR: From a review of the recent literature and the own experience based on in vitro, in silico, and in vivo studies, some reasons to explain this repetitive failure of drugs targeting Aβ are presented.