Junxia Wang

TL;DR: A thieno-isoindigo derivative-based semiconducting polymer, PBTPBF-BT, formulated into PEGylated nanoparticles exhibited strong absorption in NIR-II region, inherent high photothermal conversion efficacy, and excellent photostability, suggesting the great probability of using NPPBTP BF-BT for in vivo PA imaging-guided PTT in the Nir-II window.

TL;DR: A reactive oxygen species (ROS)-sensitive polymeric nanocarrier TK-PPE@NPCe6/DOX was explored to realize remotely controlled drug release by light-activated size shrinkage by triggering rapid DOX release.

TL;DR: The use of cascade chemo-photodynamic therapy with reactive oxygen species (ROS)-sensitive lipid-polymer hybrid nanoparticles TKHNP-C/D to potentiate the antitumor efficacy of anti-PD-L1 antibody to generate an abscopal effect which could simultaneously inhibit primary and distant tumor growth.

TL;DR: Polymeric nanoparticles observed with flowable core can achieve NIR‐activated supersensitive drug release under the assistance of photothermal agent, which significantly enhances its anticancer efficacy, resulting in overcoming of the resistance of cancer cells against DOX treatment in vitro and in vivo.

TL;DR: In vivo and in vitro experiments demonstrated that PBIBDF-BT@NPPPE exhibits efficient photothermal anticancer efficacy and could simultaneously encapsulate other types of therapeutic agents though hydrophobic interactions with the PHEP core and achieve NIR-triggered intracellular drug release and a synergistic combination therapy of thermo-chemotherapy for the treatment of cancer.