S
Song Shen
Researcher at South China University of Technology
Publications - 56
Citations - 3497
Song Shen is an academic researcher from South China University of Technology. The author has contributed to research in topics: Cancer stem cell & Immune system. The author has an hindex of 26, co-authored 51 publications receiving 2462 citations. Previous affiliations of Song Shen include University of Science and Technology of China & Center for Excellence in Education.
Papers
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Journal ArticleDOI
Smart Superstructures with Ultrahigh pH-Sensitivity for Targeting Acidic Tumor Microenvironment: Instantaneous Size Switching and Improved Tumor Penetration.
Hongjun Li,Jin-Zhi Du,Jing Liu,Xiao-Jiao Du,Song Shen,Yan Hua Zhu,Xiaoyan Wang,Xiaodong Ye,Shuming Nie,Jun Wang +9 more
TL;DR: Comparison studies of pH-sensitive and insensitive nanostructures with similar size, surface charge, and chemical composition in both multicellular spheroids and poorly permeable BxPC-3 pancreatic tumor models demonstrate that the pH-triggered size switching is a viable strategy for improving drug penetration and therapeutic efficacy.
Journal ArticleDOI
Tumor Acidity-Sensitive Polymeric Vector for Active Targeted siRNA Delivery.
Chun-Yang Sun,Song Shen,Cong-Fei Xu,Hongjun Li,Yang Liu,Zhi-Ting Cao,Xianzhu Yang,Jin-Xing Xia,Jun Wang +8 more
TL;DR: Dm-NP achieved both prolonged circulation and effective accumulation in tumor cells and resulted in the safe and enhanced inhibition of non-small cell lung cancer growth.
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Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy.
Quanyin Hu,Quanyin Hu,Wujin Sun,Jinqiang Wang,Jinqiang Wang,Huitong Ruan,Xudong Zhang,Yanqi Ye,Song Shen,Chao Wang,Weiyue Lu,Ke Cheng,Ke Cheng,Gianpietro Dotti,Joshua F. Zeidner,Jun Wang,Zhen Gu +16 more
TL;DR: It is shown that systemically delivered blood platelets decorated with anti-PD-1 antibodies and conjugated to haematopoietic stem cells reduce the growth and recurrence of leukaemia in mice and significantly augment the therapeutic efficacy of checkpoint blockade.
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Semiconducting polymer-based nanoparticles with strong absorbance in NIR-II window for in vivo photothermal therapy and photoacoustic imaging.
TL;DR: A thieno-isoindigo derivative-based semiconducting polymer, PBTPBF-BT, formulated into PEGylated nanoparticles exhibited strong absorption in NIR-II region, inherent high photothermal conversion efficacy, and excellent photostability, suggesting the great probability of using NPPBTP BF-BT for in vivo PA imaging-guided PTT in the Nir-II window.
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Restoring anti-tumor functions of T cells via nanoparticle-mediated immune checkpoint modulation
Shi-Yong Li,Yang Liu,Cong-Fei Xu,Song Shen,Rong Sun,Xiao-Jiao Du,Jin-Xing Xia,Yan-Hua Zhu,Jun Wang +8 more
TL;DR: The results demonstrated that this nanoparticle delivery system was able to deliver CTLA-4-siRNA into both CD4(+) and CD8(+) T cell subsets at tumor sites and significantly increased the percentage of anti-tumor CD8 (+) T cells, while it decreased the ratio of inhibitory T regulatory cells (Tregs) among tumor infiltrating lymphocytes (TILs).