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Jürgen Helfmann

Researcher at Charité

Publications -  49
Citations -  875

Jürgen Helfmann is an academic researcher from Charité. The author has contributed to research in topics: Scattering & Raman spectroscopy. The author has an hindex of 15, co-authored 49 publications receiving 776 citations.

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Influence of oxygen saturation on the optical scattering properties of human red blood cells in the spectral range 250 to 2000 nm

TL;DR: The intrinsic optical parameters absorption coefficient mu(a), scattering coefficient micros, anisotropy factor g, and effective scattering coefficientmicros were determined for human red blood cell suspensions of hematocrit 33.2% dependent on the oxygen saturation (SAT O(2) in the wavelength range 250 to 2,000 nm, including the range above 1,100 nm.
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Optical properties of platelets and blood plasma and their influence on the optical behavior of whole blood in the visible to near infrared wavelength range.

TL;DR: Red blood cells predominate over the other blood components by two to three orders of magnitude with regard to absorption and effective scattering, however, substituting saline solution for plasma leads to a significant increase in the effective scattering coefficient and therefore should be taken into consideration.
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Empirical model functions to calculate hematocrit-dependent optical properties of human blood

TL;DR: The absorption coefficient, scattering coefficient, and effective scattering phase function of human red blood cells in saline solution were determined for eight different hematocrits using integrating sphere measurements and inverse Monte Carlo simulation to allow for biological variability.
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In vivo study for the discrimination of cancerous and normal skin using fibre probe‐based Raman spectroscopy

TL;DR: discrimination proved to be unsuccessful between cancerous lesions and suspicious lesions that had been histopathologically verified as benign by dermoscopy, within the range of comparable in vivo studies and the accuracies achieved by trained dermatologists using dermoscop.
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Chemometric Determination of Blood Parameters Using Visible—Near-Infrared Spectra:

TL;DR: Visible and near-infrared (NIR) integrating sphere spectroscopy and chemometric multivariate linear regression were applied to determine hematocrit and oxygen saturation of circulating human blood and the calibration included the changes in hemolysis as well as inter-individual differences in cell dimensions and hemoglobin content.