J
Jurgen Schnermann
Researcher at National Institutes of Health
Publications - 282
Citations - 18375
Jurgen Schnermann is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Tubuloglomerular feedback & Macula densa. The author has an hindex of 78, co-authored 282 publications receiving 17476 citations. Previous affiliations of Jurgen Schnermann include University of Michigan & University of Rochester Medical Center.
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Journal ArticleDOI
Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture
Nanna Goldman,Michael Chen,Takumi Fujita,Qiwu Xu,Weiguo Peng,Wei Liu,Tina K Jensen,Yong Pei,Fushun Wang,Xiaoning Han,Jiang-Fan Chen,Jurgen Schnermann,Takahiro Takano,Lane K. Bekar,Kim Tieu +14 more
TL;DR: Observations indicate that adenosine mediates the effects of acupuncture and that interfering withAdenosine metabolism may prolong the clinical benefit of acupuncture.
Journal ArticleDOI
Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice
TL;DR: The data indicate that AQP1 deletion in mice results in decreased transepithelial proximal tubule water permeability and defective fluid absorption, which is primarily transcellular, mediated by AQP 1 water channels, and required for efficient near-isosmolar fluid absorption.
Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice (water transportyAQP1yurinary concentrating mechanismykidneyymicropuncture)
Jurgen Schnermann,Chung-Lin Chou,T Onghui Ma,T Imothy Traynor,Mark A. Knepper,Alan S. Verkman +5 more
TL;DR: In this article, the role of aquaporin-1 (AQP1) water channels in proximal tubule function was investigated in vitro and in vivo micropuncture measurements were done on AQP1 knockout mice.
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Mediation of tubuloglomerular feedback by adenosine: Evidence from mice lacking adenosine 1 receptors
Daqing Sun,Linda C. Samuelson,Tianxin Yang,Yuning Huang,Alex Paliege,Thom Saunders,Josie P. Briggs,Jurgen Schnermann +7 more
TL;DR: A1AR null mutant mice are a promising tool to study the functional role of A1AR in different target tissues and suggest that adenosine is a required constituent of the juxtaglomerular signaling pathway.
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Reduced Production of Creatinine Limits Its Use as Marker of Kidney Injury in Sepsis
Kent Doi,Peter S.T. Yuen,Christoph Eisner,Xuzhen Hu,Asada Leelahavanichkul,Jurgen Schnermann,Robert A. Star +6 more
TL;DR: In mice, induction of sepsis by cecal ligation and puncture in bilaterally nephrectomized mice increased markers of nonrenal organ injury and serum TNF-alpha, but serum creatinine was significantly lower in septic animals than in animals subjected to bilateral neph rectomy and sham cecals, supporting the need for new biomarkers that provide better measures of renal injury.