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Xiaoning Han
Researcher at Johns Hopkins University School of Medicine
Publications - 33
Citations - 8614
Xiaoning Han is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Intracerebral hemorrhage & Microglia. The author has an hindex of 29, co-authored 33 publications receiving 6989 citations. Previous affiliations of Xiaoning Han include University of Rochester Medical Center & University of Rochester.
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Journal ArticleDOI
Uniquely hominid features of adult human astrocytes
Nancy Ann Oberheim,Takahiro Takano,Xiaoning Han,Wei He,Jane H.-C. Lin,Fushun Wang,Qiwu Xu,Jeffrey D. Wyatt,Webster H. Pilcher,Jeffrey G. Ojemann,Bruce R. Ransom,Steven A. Goldman +11 more
TL;DR: It is reported here that protoplasmic astrocytes in human neocortex are 2.6-fold larger in diameter and extend 10-fold more GFAP (glial fibrillary acidic protein)-positive primary processes than their rodent counterparts, and it is posited that thisAstrocytic complexity has permitted the increased functional competence of the adult human brain.
Journal ArticleDOI
Astrocyte-mediated control of cerebral blood flow.
Takahiro Takano,Guo-Feng Tian,Weiguo Peng,Nanhong Lou,Witold Libionka,Witold Libionka,Xiaoning Han +6 more
TL;DR: It is shown that cortical astrocytes in vivo possess a powerful mechanism for rapid vasodilation and are implicated in the control of local microcirculation and suggest that one of their physiological roles is to mediate vasodilated in response to increased neural activity.
Journal ArticleDOI
Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture
Nanna Goldman,Michael Chen,Takumi Fujita,Qiwu Xu,Weiguo Peng,Wei Liu,Tina K Jensen,Yong Pei,Fushun Wang,Xiaoning Han,Jiang-Fan Chen,Jurgen Schnermann,Takahiro Takano,Lane K. Bekar,Kim Tieu +14 more
TL;DR: Observations indicate that adenosine mediates the effects of acupuncture and that interfering withAdenosine metabolism may prolong the clinical benefit of acupuncture.
Journal ArticleDOI
Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo.
Xiaohai Wang,Nanhong Lou,Qiwu Xu,Guo-Feng Tian,Weiguo Peng,Xiaoning Han,Jian Kang,Takahiro Takano +7 more
TL;DR: It is shown that whisker stimulation evokes increases in astrocytic cytosolic calcium (Ca2+) within the barrel cortex of adult mice, and that increases in Astrocytic Ca2+ occur independently of postsynaptic excitatory activity.
Journal ArticleDOI
Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice
Xiaoning Han,Michael Chen,Fushun Wang,Martha S. Windrem,Su Wang,Steven Shanz,Qiwu Xu,Nancy Ann Oberheim,Lane K. Bekar,Sarah J. Betstadt,Alcino J. Silva,Takahiro Takano,Steven A. Goldman +12 more
TL;DR: It is indicated that human glia differentially enhance both activity-dependent plasticity and learning in mice.