J
Jürgen Wagner
Researcher at Scripps Research Institute
Publications - 3
Citations - 468
Jürgen Wagner is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Hajos–Parrish–Eder–Sauer–Wiechert reaction & Nucleophile. The author has an hindex of 3, co-authored 3 publications receiving 452 citations.
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Efficient aldolase catalytic antibodies that use the enamine mechanism of natural enzymes
TL;DR: Antibodies that catalyze the aldol reaction, a basic carbon-carbon bond-forming reaction, have been generated using the ϵ-amino group of Lys to form an enamine with ketone substrates and use this enamine as a nascent carbon nucleophile to attack the second substrate, an aldehyde, to form a new carbon- carbon bond.
Journal ArticleDOI
Synthetic Human Antibodies: Selecting and Evolving Functional Proteins
Carlos F. Barbas,Jürgen Wagner +1 more
TL;DR: Phage display of antibody fragments provides a convenient format for directed molecular evolution of this biologically important protein architecture and methods have been developed for the mechanism-based selection of catalytic antibodies.
Journal ArticleDOI
Synthesis of five enantiomerically pure haptens designed for in vitro evolution of antibodies with peptidase activity.
TL;DR: Since mechanism based selections result in covalent trapping of species from libraries, diol and disulfide containing haptenic linkers were developed for the oxidative or reductive release of selected catalysts.