1,2-Amino Alcohols and Their Heterocyclic Derivatives as Chiral Auxiliaries in Asymmetric Synthesis

Recent developments in the stereoselective synthesis of α-aminoacids

The chemistry of 2-oxazolines (1985–present)

Macrolactonizations in the Total Synthesis of Natural Products

Products A. Parenty,† X. Moreau,†,§ Gilles Niel,‡ and J.-M. Campagne*,†,‡ †Institut de Chimie des Substances Naturelles, Avenue de la Terrasse, F-91198 Gif sur Yvette, France Institut Lavoisier de Versailles, UMR CNRS 8180, Universite ́ de Versailles-Saint-Quentin-en-Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France ‡Institut Charles Gerhardt, UMR5253, Ecole Nationale Supeŕieure de Chimie, 8 rue de l’Ecole Normale, F-34296 Montpellier, France

Update 1 of: macrolactonizations in the total synthesis of natural products.

Amino Acids and Peptides; 70.1 Optically Active α-Amino Acids, N-Boc-Aminoaldehydes and α-Amino-β-hydroxy Acid from 2,3-Epoxy Alcohols

Synthese von (+)- und (−)-Homononactinsäure: Totalsynthese des Makrotetrolids Tetranactin durch Reverse Coupe du Roï ― Strukturvorschlag für Isodinactin

The synthesis of (+)- and (–)-homononactic acid was achieved in 6 steps and 4 steps respectively starting with the reaction of 2-lithium-5-vinylfuran and (S)-(–)-1,2-epoxybutane; both enantiomers were used in the construction of the achiral macrolide antibiotic tetranactin by esterification and subsequent lactonisation with the thiolester of 3-cyano-4,6-dimethyl-2-thiopyridone.

Jürgen Werner

Papers

Amino Acids and Peptides; 70.1 Optically Active α-Amino Acids, N-Boc-Aminoaldehydes and α-Amino-β-hydroxy Acid from 2,3-Epoxy Alcohols

Synthese von (+)- und (−)-Homononactinsäure: Totalsynthese des Makrotetrolids Tetranactin durch Reverse Coupe du Roï ― Strukturvorschlag für Isodinactin

Synthesis of (+)- and (–)-homononactic acid from (S)-1,2-epoxybutane. Total synthesis of tetranactin by ‘reverse coupe du roi’