J
Justin J. Maresh
Researcher at DePaul University
Publications - 14
Citations - 1340
Justin J. Maresh is an academic researcher from DePaul University. The author has contributed to research in topics: One-pot synthesis & Indole test. The author has an hindex of 9, co-authored 14 publications receiving 1182 citations. Previous affiliations of Justin J. Maresh include Massachusetts Institute of Technology & Emory University.
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Journal ArticleDOI
Chemistry and biology of monoterpene indole alkaloid biosynthesis
TL;DR: The biosynthetic pathways for several representative terpene indole alkaloids are described in detail, showing a diverse array of structures and biological activities.
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Strictosidine synthase: mechanism of a Pictet-Spengler catalyzing enzyme.
Justin J. Maresh,Lesley-Ann Giddings,Anne Friedrich,Elke A. Loris,Santosh Panjikar,Bernhardt L. Trout,Joachim Stöckigt,Baron Peters,Sarah E. O'Connor +8 more
TL;DR: The role that the biosynthetic enzyme strictosidine synthase plays in catalyzing the stereoselective synthesis of a beta-carboline product is deconvolute and the structures of possible productive transition states involved in the mechanism are suggested.
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Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture
TL;DR: It is shown that RNA mediated suppression of tryptamine biosynthesis in Catharanthus roseus hairy root culture eliminates all production of monoterpene indole alkaloids, a class of natural products derived from two starting substrates, tryptamines and secologanin, which appears to be a viable strategy for programming a plant alkaloid pathway to more effectively produce desirable unnatural products.
Journal ArticleDOI
Chemistry and Biology of Monoterpene Indole Alkaloid Biosynthesis
TL;DR: In this article, the biosynthetic pathways for several representative terpene indole alkaloids are described in detail, up to 2006 and up to the present day, in detail.
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Chemical biology of multi-host/pathogen interactions: chemical perception and metabolic complementation.
TL;DR: The xenognostic mechanisms of two multi-host pathogens, the causative agent of crown gall tumors Agrobacterium tumefaciens and the parasitic plant Striga asiatica, are compared and two mechanistic strategies, chemical perception and metabolic complementation, are used to ensure successful host commitment.