Journal ArticleDOI
Chemistry and biology of monoterpene indole alkaloid biosynthesis
TLDR
The biosynthetic pathways for several representative terpene indole alkaloids are described in detail, showing a diverse array of structures and biological activities.About:
This article is published in Natural Product Reports.The article was published on 2006-07-25. It has received 761 citations till now. The article focuses on the topics: Indole test & Strictosidine.read more
Citations
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De novo production of the plant-derived alkaloid strictosidine in yeast
TL;DR: It is demonstrated how strictosidine can be produced de novo in a Saccharomyces cerevisiae host from 14 known monoterpene indole alkaloid pathway genes, along with an additional seven genes and three gene deletions that enhance secondary metabolism.
Journal ArticleDOI
Squalene: A natural triterpene for use in disease management and therapy.
TL;DR: This paper is the first review of its kind and offers greater insight into squalene's direct or indirect contribution to disease management and therapy.
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The Transcription Factor CrWRKY1 Positively Regulates the Terpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus
Nitima Suttipanta,Sitakanta Pattanaik,Manish Kulshrestha,Barunava Patra,Sanjay Singh,Ling Yuan +5 more
TL;DR: The preferential expression of CrWRKY1 in roots and its interaction with transcription factors including ORCA3, CrMYC2, and ZCTs may play a key role in determining the root-specific accumulation of serpentine in C. roseus plants.
Journal ArticleDOI
The rise of chemodiversity in plants.
TL;DR: Compared with their evolutionarily constrained counterparts in primary metabolism, specialized metabolic enzymes may be more tolerant to mutations normally considered destabilizing to protein structure and function, and may partially explain the pronounced chemodiversity of terrestrial plants.
The Transcription Factor CrWRKY1 Positively Regulates the Terpenoid Indole Alkaloid Biosynthesis in
Nitima Suttipanta,Sitakanta Pattanaik,Manish Kulshrestha,Barunava Patra,Sanjay Singh,Ling Yuan,Kentucky Tobacco +6 more
TL;DR: In this paper, Manish Kulshrestha, Barunava Patra, Sanjay K. Singh, and Ling Yuan have discussed the effects of smoking on plant and soil sciences.
References
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Journal ArticleDOI
Medicinal Natural Products: A Biosynthetic Approach
Geoffrey C. Kite,Paul M. Dewick +1 more
TL;DR: In this paper, the authors present an approach for the construction of blocks and constructions of machinery for primary and secondary metabolic systems based on the properties of the building blocks and the construction mechanism.
Journal ArticleDOI
The Pictet-Spengler condensation: a new direction for an old reaction
Eric Cox,James M. Cook +1 more
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The Catharanthus alkaloids: pharmacognosy and biotechnology.
TL;DR: Despite the availability of only a limited number of biosynthetic genes, the research on C. roseus has already led to a broad scientific spin-off and it is clear that many interesting results can be expected when more genes become available.
Journal ArticleDOI
Biosynthesis of isoprenoids via the non-mevalonate pathway
TL;DR: The mevalonate pathway is essential in plants, many eubacteria and apicomplexan parasites, but not in archaea and animals, and detailed knowledge about the mechanisms may benefit the development of novel antibiotics, antimalarials and herbicides.
Journal ArticleDOI
ALKALOID BIOSYNTHESIS IN PLANTS: Biochemistry, Cell Biology, Molecular Regulation, and Metabolic Engineering Applications.
TL;DR: The early events of signal perception, the pathways of signal transduction, and the function of gene promoters have been studied in relation to the regulation of alkaloid metabolism.