J
Jyoti J. Watters
Researcher at University of Wisconsin-Madison
Publications - 103
Citations - 5530
Jyoti J. Watters is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Microglia & Intermittent hypoxia. The author has an hindex of 37, co-authored 87 publications receiving 4971 citations. Previous affiliations of Jyoti J. Watters include University of Washington & Case Western Reserve University.
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Journal ArticleDOI
Rapid Membrane Effects of Steroids in Neuroblastoma Cells: Effects of Estrogen on Mitogen Activated Protein Kinase Signalling Cascade and c-fos Immediate Early Gene Transcription
TL;DR: It is shown that in the human neuroblastoma cell line SK-N-SH, the membrane impermeable conjugated 17beta-estradiol (E2BSA) activates mitogen activated protein kinase kinase (MAPKK or MEK) and induces the phosphorylation and activation of both ERK-1 and ERK
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BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia
Tracy L. Baker-Herman,David D. Fuller,Ryan W. Bavis,A. G. Zabka,Francis J. Golder,Nicholas J. Doperalski,Rebecca A. Johnson,Jyoti J. Watters,Gordon S. Mitchell +8 more
TL;DR: It is found that intermittent hypoxia elicited serotonin-dependent increases in BDNF synthesis in ventral spinal segments containing the phrenic nucleus, and the magnitude of these BDNF increases correlated with pLTF magnitude.
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Microglia function in brain tumors.
TL;DR: A better understanding of microglia and macrophage function is essential for the development of immune‐based treatment strategies against malignant brain tumors.
Journal ArticleDOI
Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice.
TL;DR: Age‐ and sex‐specific variances in basal gene expression may allow differential microglial responses to the same stimulus at different ages, perhaps contributing to altered CNS vulnerabilities and/or disease courses.
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Estrogen rapidly induces the phosphorylation of the cAMP response element binding protein in rat brain.
TL;DR: These data provide evidence for non-genomic effects of steroid hormones involving protein kinase associated signal transduction pathways traditionally associated with effects at the cell membrane and provide a possible explanation for estrogen's effects on neuronal genes lacking estrogen response elements but which contain cAMP response elements.