K
K Otfried Schwab
Researcher at University of Freiburg
Publications - 21
Citations - 1144
K Otfried Schwab is an academic researcher from University of Freiburg. The author has contributed to research in topics: Population & Body mass index. The author has an hindex of 16, co-authored 21 publications receiving 972 citations. Previous affiliations of K Otfried Schwab include University Medical Center Freiburg & Boston Children's Hospital.
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Journal ArticleDOI
Spectrum and Prevalence of Atherogenic Risk Factors in 27,358 Children, Adolescents, and Young Adults With Type 1 Diabetes: Cross-sectional data from the German diabetes documentation and quality management system (DPV)
K Otfried Schwab,Jürgen Doerfer,Wolfgang Hecker,Jürgen Grulich-Henn,Dagobert Wiemann,Olga Kordonouri,Peter Beyer,Reinhard W. Holl +7 more
TL;DR: With increasing age, a greater number of patients with cardiovascular risk factors were observed and early identification, prevention, and treatment of additional risk factors seem to be necessary, particularly in light of the high incidence of future cardiovascular disease.
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A Phase 3 Trial of Sebelipase Alfa in Lysosomal Acid Lipase Deficiency.
Barbara K. Burton,Manisha Balwani,François Feillet,Ivo Barić,T. Andrew Burrow,Carmen Camarena Grande,Mahmut Çoker,Alejandra Consuelo-Sanchez,Patrick Deegan,Maja Di Rocco,Gregory M. Enns,Richard W. Erbe,Fatih Süheyl Ezgü,Can Ficicioglu,Katryn N. Furuya,John P. Kane,Christina M. Laukaitis,Eugen Mengel,Edward G. Neilan,Scott Nightingale,Heidi Peters,Maurizio Scarpa,K Otfried Schwab,Vratislav Smolka,Vassili Valayannopoulos,Marnie Wood,Zachary Goodman,Yijun Yang,Stephen Eckert,Sandra Rojas-Caro,Anthony G. Quinn +30 more
TL;DR: Sbelipase alfa therapy resulted in a reduction in multiple disease-related hepatic and lipid abnormalities in children and adults with lysosomal acid lipase deficiency and observed improvements in lipid levels and reduction in hepatic fat content.
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Mutations in SELENBP1, encoding a novel human methanethiol oxidase, cause extraoral halitosis.
Arjan Pol,G. Herma Renkema,Albert Tangerman,Edwin Winkel,Udo F. H. Engelke,Arjan P.M. de Brouwer,Kevin C K Lloyd,Renee S. Araiza,Lambert P. van den Heuvel,Heymut Omran,Heike Olbrich,Marijn Oude Elberink,Christian Gilissen,Richard J. Rodenburg,Jörn Oliver Sass,K Otfried Schwab,Hendrik Schäfer,Hanka Venselaar,J. Silvia Sequeira,Huub J. M. Op den Camp,Ron A. Wevers +20 more
TL;DR: It is found that enzyme deficiency leads to increased levels of methanethiol and dimethylsulfide in the breath and that knockout mice have similar biochemical phenotypes, similar to those in humans.
Journal ArticleDOI
Clinical and neurocognitive outcome in symptomatic isovaleric acidemia.
Sarah C. Grünert,Udo Wendel,Martin Lindner,Michael Leichsenring,K Otfried Schwab,Jerry Vockley,Willy Lehnert,Regina Ensenauer +7 more
TL;DR: Within the group of "classical" organic acidurias, IVA appears to be exceptional considering its milder neuropathologic implications, and the potential to avoid neonatal mortality and to improve neurologic and cognitive outcome under early treatment reinforces IVA to be qualified for newborn screening.
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Characterization of 33 488 children and adolescents with type 1 diabetes based on the gender-specific increase of cardiovascular risk factors.
TL;DR: Characterization of 33 488 children and adolescents with type 1 diabetes based on the gender‐specific increase of cardiovascular risk factors shows clear gender-specific differences in the risks experienced by boys and girls.