K
K T Uysal
Researcher at Harvard University
Publications - 6
Citations - 3167
K T Uysal is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Receptor. The author has an hindex of 6, co-authored 6 publications receiving 3036 citations.
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Journal ArticleDOI
Protection from obesity-induced insulin resistance in mice lacking TNF-|[alpha]| function
TL;DR: Results indicate that TNF-α is an important mediator of insulin resistance in obesity through its effects on several important sites of insulin action.
Journal ArticleDOI
Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes.
TL;DR: Evidence is provided that TNF-alpha can act directly on adipocytes to regulate the release of a preformed pool of leptin and that the elevated adipose tissue expression of T NF-alpha that occurs in obesity may contribute to obesity-related hyperleptinemia.
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Functional analysis of tumor necrosis factor (TNF) receptors in TNF-alpha-mediated insulin resistance in genetic obesity.
TL;DR: Results indicate that TNF-alpha is a component of insulin resistance in the ob/ob model of murine obesity and p55 TNFR is the predominant receptor mediating its actions.
Journal ArticleDOI
Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice.
Ludger Scheja,Liza Makowski,K T Uysal,S M Wiesbrock,D R Shimshek,D S Meyers,M Morgan,R A Parker,Gökhan S. Hotamisligil +8 more
TL;DR: Support is provided for the existence of an adipo-pancreatic axis and aP2's role in the pathogenesis of type 2 diabetes might involve regulation of both hyperinsulinemia and insulin resistance through its impact on both lipolysis and insulin secretion.
Journal ArticleDOI
Tumor necrosis factor α mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity
Enzo Nisoli,L. Briscini,Antonio Giordano,Cristina Tonello,S M Wiesbrock,K T Uysal,Saverio Cinti,Michele O. Carruba,Gökhan S. Hotamisligil +8 more
TL;DR: Results indicate that TNF-alpha plays an important role in multiple aspects of brown adipose tissue biology and mediates the abnormalities that occur at this site in obesity.