Enzo Nisoli

TL;DR: The mitochondrial biogenesis induced by exposure to cold was markedly reduced in brown adipose tissue of endothelial nitric oxide synthase null-mutant (eNOS–/–) mice, which had a reduced metabolic rate and accelerated weight gain as compared to wild-type mice.

TL;DR: It is shown that the lack of CB1 in mice with a disrupted CB1 gene causes hypophagia and leanness, and the cannabinoid system is an essential endogenous regulator of energy homeostasis via central orexigenic as well as peripheral lipogenic mechanisms and might therefore represent a promising target to treat diseases characterized by impaired energy balance.

TL;DR: Nitric oxide plays a fundamental role in the processes induced by calorie restriction and may be involved in the extension of life span in mammals.

TL;DR: It is reported that the NO/cGMP-dependent mitochondrial biogenesis is associated with enhanced coupled respiration and content of ATP in U937, L6, and PC12 cells, and that this stimulation isassociated with increased mitochondrial function, resulting in enhanced formation of ATP.

TL;DR: It is shown that a BCAA-enriched mixture (BCAAem) increased the average life span of mice and revealed an important antiaging role of BCAAs mediated by mitochondrial biogenesis in mammals.