M
Michele O. Carruba
Researcher at University of Milan
Publications - 116
Citations - 7409
Michele O. Carruba is an academic researcher from University of Milan. The author has contributed to research in topics: Mitochondrial biogenesis & Adipose tissue. The author has an hindex of 37, co-authored 107 publications receiving 6828 citations. Previous affiliations of Michele O. Carruba include University of Padua & University of Cagliari.
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Journal ArticleDOI
Mitochondrial biogenesis in mammals: The role of endogenous nitric oxide
Enzo Nisoli,Emilio Clementi,Clara Paolucci,Valeria Cozzi,Cristina Tonello,Clara Sciorati,Renata Bracale,Alessandra Valerio,Maura Francolini,Salvador Moncada,Michele O. Carruba +10 more
TL;DR: The mitochondrial biogenesis induced by exposure to cold was markedly reduced in brown adipose tissue of endothelial nitric oxide synthase null-mutant (eNOS–/–) mice, which had a reduced metabolic rate and accelerated weight gain as compared to wild-type mice.
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Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS
Enzo Nisoli,Cristina Tonello,A Cardile,Valeria Cozzi,Renata Bracale,Laura Tedesco,Sestina Falcone,Alessandra Valerio,Orazio Cantoni,Emilio Clementi,Emilio Clementi,Salvador Moncada,Michele O. Carruba +12 more
TL;DR: Nitric oxide plays a fundamental role in the processes induced by calorie restriction and may be involved in the extension of life span in mammals.
Journal ArticleDOI
Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals
Enzo Nisoli,Sestina Falcone,Cristina Tonello,Valeria Cozzi,Letizia Palomba,Mara Fiorani,Addolorata Pisconti,Silvia Brunelli,A Cardile,Maura Francolini,Orazio Cantoni,Michele O. Carruba,Salvador Moncada,Emilio Clementi +13 more
TL;DR: It is reported that the NO/cGMP-dependent mitochondrial biogenesis is associated with enhanced coupled respiration and content of ATP in U937, L6, and PC12 cells, and that this stimulation isassociated with increased mitochondrial function, resulting in enhanced formation of ATP.
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Branched-Chain Amino Acid Supplementation Promotes Survival and Supports Cardiac and Skeletal Muscle Mitochondrial Biogenesis in Middle-Aged Mice
Giuseppe D'Antona,Maurizio Ragni,A Cardile,Laura Tedesco,Marta Dossena,Marta Dossena,Flavia Bruttini,Francesca Caliaro,Giovanni Corsetti,Roberto Bottinelli,Michele O. Carruba,Alessandra Valerio,Alessandra Valerio,Enzo Nisoli +13 more
TL;DR: It is shown that a BCAA-enriched mixture (BCAAem) increased the average life span of mice and revealed an important antiaging role of BCAAs mediated by mitochondrial biogenesis in mammals.
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TNF-α downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents
Alessandra Valerio,A Cardile,Valeria Cozzi,Renata Bracale,Laura Tedesco,Addolorata Pisconti,Letizia Palomba,Orazio Cantoni,Emilio Clementi,Salvador Moncada,Michele O. Carruba,Enzo Nisoli +11 more
TL;DR: It is demonstrated that eNOS expression was reduced, with a concomitant reduction of mitochondrial biogenesis and function, in white and brown adipose tissue and in the soleus muscle of 3 different animal models of obesity.