K
Kadri Kangro
Researcher at Katholieke Universiteit Leuven
Publications - 18
Citations - 501
Kadri Kangro is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Autoantibody & Antibody. The author has an hindex of 4, co-authored 13 publications receiving 62 citations.
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Journal ArticleDOI
Dynamics of antibody response to BNT162b2 vaccine after six months: a longitudinal prospective study.
Paul Naaber,Paul Naaber,Liina Tserel,Kadri Kangro,Epp Sepp,Virge Jürjenson,Ainika Adamson,Liis Haljasmägi,Anna Pauliina Rumm,Regina Maruste,Jaanika Kärner,Joachim M. Gerhold,Anu Planken,Mart Ustav,Kai Kisand,Pärt Peterson +15 more
TL;DR: In this paper, the antibody and memory T cell responses after the two-dose BNT162b2 vaccine in 122 volunteers up to 6 months and correlated the findings with age and side effects.
Journal ArticleDOI
Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura.
Elien Roose,Gestur Vidarsson,Kadri Kangro,O. J. H. M. Verhagen,Ilaria Mancini,Linda Desender,Inge Pareyn,Nele Vandeputte,Aline Vandenbulcke,Chiara Vendramin,An Sofie Schelpe,Jan Voorberg,Marie-Agnès Azerad,Laurent Gilardin,Marie Scully,Daan Dierickx,Hans Deckmyn,Simon F. De Meyer,Flora Peyvandi,Flora Peyvandi,Karen Vanhoorelbeke +20 more
TL;DR: Three of the five cloned IgG antibodies, TTP73-1, ELH2-1 and TR8C11, indeed recognize ADAMTS13, and these data nicely fit the recent finding that the conformation of ADAMts13 is open during acute iTTP.
Journal ArticleDOI
Modifying ADAMTS13 to modulate binding of pathogenic autoantibodies of patients with acquired thrombotic thrombocytopenic purpura.
Nuno A. G. Graça,Bogac Ercig,Leydi Carolina Velásquez Pereira,Kadri Kangro,Paul H. P. Kaijen,Gerry A. F. Nicolaes,Agnès Veyradier,Paul Coppo,Karen Vanhoorelbeke,Andres Männik,Jan Voorberg +10 more
TL;DR: It is shown that non-conservative and alanine modifications of residues within the exosite-3 spacer RFRYY epitope in full-length ADAMTS13 resist the binding of autoantibodies from iTTP patients, while retaining residual proteolytic activity.
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Immunogenic hotspots in the spacer domain of ADAMTS13 in immune-mediated thrombotic thrombocytopenic purpura.
Leydi Carolina Velásquez Pereira,Elien Roose,Nuno A. G. Graça,György Sinkovits,Kadri Kangro,Bérangère S. Joly,Edwige Tellier,Gilles Kaplanski,Tanja Falter,Charis von Auer,Heidi Rossmann,Hendrik B. Feys,Marienn Réti,Zoltán Prohászka,Bernhard Lämmle,Bernhard Lämmle,Bernhard Lämmle,Jan Voorberg,Paul Coppo,Agnès Veyradier,Simon F. De Meyer,Andres Männik,Karen Vanhoorelbeke +22 more
TL;DR: Epitope mapping studies on samples obtained during acute iTTP episodes have shown that the iTTP immune response is polyclonal, with almost all patients having autoantibodies targeting the spacer domain of ADAMTS13.
Journal ArticleDOI
Protective antibodies and T cell responses to Omicron variant after the booster dose of BNT162b2 vaccine
Paul Naaber,Liina Tserel,Kadri Kangro,Marite Punapart,Epp Sepp,Virge Jürjenson,Jaanika Kärner,Liis Haljasmägi,Uku Haljasorg,Marilin Kuusk,Eve Sankovski,Anu Planken,Mart Ustav,Eva Zusinaite,Joachim M. Gerhold,Kai Kisand,Pärt Peterson +16 more
TL;DR: In this article , the authors report a longitudinal analysis of 111 vaccinated individuals for their antibody levels up to 6 months after the third dose of the BNT162b2 vaccine, and they show that the third vaccination restores the high levels of blocking antibodies and enhances T cell responses to Omicron.