Gilles Kaplanski

TL;DR: A surveillance model is proposed: these receptors "keep watch" for both endogenous and exogenous molecules that indicate tissue inquiry, infection and remodeling, and it is suggested that the first Toll-like family receptors that arose in evolution might have acted in both development and immunity by recognizing the degradation of endogenous macromolecules.

TL;DR: The biology of IL-18 is reviewed as well as its role in human disease, which has been implicated in several autoimmune diseases, myocardial function, emphysema, metabolic syndromes, psoriasis, inflammatory bowel disease, hemophagocytic syndrome, macrophage activation syndrome, sepsis, and acute kidney injury.

TL;DR: There is now ample evidence for a role of IL‐18 in various infectious, metabolic or inflammatory diseases such as influenza virus infection, atheroma, myocardial infarction, chronic obstructive pulmonary disease, or Crohn's disease, however,IL‐18 plays a very specific role in the pathogenesis of hemophagocytic syndromes also termed Macrophage Activation Syndrome.

TL;DR: The aim of this study was to improve characterization of the blood IFN signature in adult SLE patients.

TL;DR: IL-18 is defined as an immunosuppressive cytokine in cancer because it promotes the development of NK-controlled metastases in a PD-1-dependent manner and novel clinical implementations of anti-PD-1 antibodies in human malignancies that produce IL-18 are suggested.