K
Kai Tashiro
Researcher at Kyoto University
Publications - 1
Citations - 733
Kai Tashiro is an academic researcher from Kyoto University. The author has contributed to research in topics: Gene & Chemokine receptor. The author has an hindex of 1, co-authored 1 publications receiving 730 citations.
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Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant
Cheryl A. Winkler,William S. Modi,Michael W. Smith,George W. Nelson,Xueyun Wu,Mary Carrington,Michael Dean,Tasaku Honjo,Kai Tashiro,Daisuke Yabe,Susan Buchbinder,Eric Vittinghoff,James J. Goedert,Thomas R. O'Brien,Lisa P. Jacobson,Roger Detels,Sharyne Donfield,Anne Willoughby,Edward D. Gomperts,David Vlahov,John P. Phair,Stephen J. O'Brien +21 more
TL;DR: The recessive protective effect of SDF1-3'A was increasingly pronounced in individuals infected with HIV-1 for longer periods, was twice as strong as the dominant genetic restriction of AIDS conferred by CCR5 and CCR2 chemokine receptor variants in these populations, and was complementary with these mutations in delaying the onset of AIDS.