Journal ArticleDOI
Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant
Cheryl A. Winkler,William S. Modi,Michael W. Smith,George W. Nelson,Xueyun Wu,Mary Carrington,Michael Dean,Tasaku Honjo,Kai Tashiro,Daisuke Yabe,Susan Buchbinder,Eric Vittinghoff,James J. Goedert,Thomas R. O'Brien,Lisa P. Jacobson,Roger Detels,Sharyne Donfield,Anne Willoughby,Edward D. Gomperts,David Vlahov,John P. Phair,Stephen J. O'Brien +21 more
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TLDR
The recessive protective effect of SDF1-3'A was increasingly pronounced in individuals infected with HIV-1 for longer periods, was twice as strong as the dominant genetic restriction of AIDS conferred by CCR5 and CCR2 chemokine receptor variants in these populations, and was complementary with these mutations in delaying the onset of AIDS.Abstract:
Stromal-derived factor (SDF-1) is the principal ligand for CXCR4, a coreceptor with CD4 for T lymphocyte cell line-tropic human immunodeficiency virus-type 1 (HIV-1). A common polymorphism, SDF1-3'A, was identified in an evolutionarily conserved segment of the 3' untranslated region of the SDF-1 structural gene transcript. In the homozygous state, SDF1-3'A/3'A delays the onset of acquired immunodeficiency syndrome (AIDS), according to a genetic association analysis of 2857 patients enrolled in five AIDS cohort studies. The recessive protective effect of SDF1-3'A was increasingly pronounced in individuals infected with HIV-1 for longer periods, was twice as strong as the dominant genetic restriction of AIDS conferred by CCR5 and CCR2 chemokine receptor variants in these populations, and was complementary with these mutations in delaying the onset of AIDS.read more
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CHEMOKINE RECEPTORS AS HIV-1 CORECEPTORS: Roles in Viral Entry, Tropism, and Disease
TL;DR: In this paper, the chemokine receptors CXCR4 and CCR5, members of the G protein-coupled receptor superfamily, have been identified as the principal coreceptors for T cell line-tropic and macrophagetropic HIV-1 isolates, respectively.
Journal Article
International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors
Philip M. Murphy,Marco Baggiolini,Israel F. Charo,Caroline A. Hébert,Richard Horuk,Kouji Matsushima,Louis H. Miller,Joost J. Oppenheim,Christine A. Power +8 more
TL;DR: A widely accepted receptor nomenclature system is described, ratified by the International Union of Pharmacology, that is facilitating clear communication in this area and updating current concepts of the biology and pharmacology of the chemokine system.
Journal ArticleDOI
Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infection
Raj Shankarappa,Joseph B. Margolick,Stephen J. Gange,Allen G. Rodrigo,David Upchurch,Homayoon Farzadegan,Phalguni Gupta,Charles R. Rinaldo,Gerald H. Learn,Xi C. He,Xiao Li Huang,James I. Mullins +11 more
TL;DR: In this article, the authors studied the evolution of the C2-V5 region of the HIV-1 env gene and of T-cell subsets in nine men with a moderate or slow rate of disease progression.
Journal ArticleDOI
Human Immunodeficiency Virus Controllers: Mechanisms of Durable Virus Control in the Absence of Antiretroviral Therapy
TL;DR: It is indicated that as with other potentially pathogenic chronic viral infections, the human immune system is able to fully control HIV and prevent HIV-associated disease, at least in some individuals.
Journal ArticleDOI
Chemokine receptors: multifaceted therapeutic targets.
TL;DR: The rationale for developing antagonists of chemokine receptors for inflammatory disorders and AIDS, and the accumulating evidence that favours this strategy despite the apparent redundancy in the chemokines system are focused on.
References
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