M
Michael W. Smith
Researcher at Johns Hopkins University
Publications - 147
Citations - 15736
Michael W. Smith is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Single-nucleotide polymorphism & Medicine. The author has an hindex of 47, co-authored 123 publications receiving 15028 citations. Previous affiliations of Michael W. Smith include Science Applications International Corporation & Columbia University.
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Journal ArticleDOI
Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene
Michael Dean,Mary Carrington,Cheryl A. Winkler,Gavin A. Huttley,Michael W. Smith,Rando Allikmets,James J. Goedert,Susan Buchbinder,Eric Vittinghoff,Edward D. Gomperts,Sharyne Donfield,David Vlahov,Richard A. Kaslow,Alfred J. Saah,Charles R. Rinaldo,Roger Detels,Stephen J. O'Brien +16 more
TL;DR: The CKR5Δ32 deletion may act as a recessive restriction gene against HIV-1 infection and may exert a dominant phenotype of delaying progression to AIDS among infected individuals.
Journal ArticleDOI
The Genetic Structure and History of Africans and African Americans
Sarah A. Tishkoff,Floyd A. Reed,Françoise R. Friedlaender,Christopher Ehret,Alessia Ranciaro,Alessia Ranciaro,Alessia Ranciaro,Alain Froment,Jibril Hirbo,Jibril Hirbo,Agnes A. Awomoyi,Jean-Marie Bodo,Ogobara K. Doumbo,Muntaser E. Ibrahim,Abdalla T. Juma,Maritha J. Kotze,Godfrey Lema,Jason H. Moore,Holly M. Mortensen,Thomas B. Nyambo,Sabah A. Omar,Kweli Powell,Gideon S. Pretorius,Michael W. Smith,Mahamadou A. Thera,Charles Wambebe,James L. Weber,Scott M. Williams +27 more
TL;DR: A detailed genetic analysis of most major groups of African populations is provided, suggesting that Africans represent 14 ancestral populations that correlate with self-described ethnicity and shared cultural and/or linguistic properties.
Journal ArticleDOI
Contrasting Genetic Influence of CCR2 and CCR5 Variants on HIV-1 Infection and Disease Progression
Michael W. Smith,Michael Dean,Mary Carrington,Cheryl A. Winkler,Gavin A. Huttley,Deborah A. Lomb,James J. Goedert,Thomas R. O'Brien,Lisa P. Jacobson,Richard A. Kaslow,Susan Buchbinder,Eric Vittinghoff,David Vlahov,Keith Hoots,Margaret W. Hilgartner,Stephen J. O'Brien +15 more
TL;DR: Genetic association analysis of five acquired immunodeficiency syndrome (AIDS) cohorts revealed that although CCR2-64I exerts no influence on the incidence of HIV- 1 infection, HIV-1-infected individuals carrying the C CR2- 64I allele progressed to AIDS 2 to 4 years later than individuals homozygous for the common allele.
Journal ArticleDOI
Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant
Cheryl A. Winkler,William S. Modi,Michael W. Smith,George W. Nelson,Xueyun Wu,Mary Carrington,Michael Dean,Tasaku Honjo,Kai Tashiro,Daisuke Yabe,Susan Buchbinder,Eric Vittinghoff,James J. Goedert,Thomas R. O'Brien,Lisa P. Jacobson,Roger Detels,Sharyne Donfield,Anne Willoughby,Edward D. Gomperts,David Vlahov,John P. Phair,Stephen J. O'Brien +21 more
TL;DR: The recessive protective effect of SDF1-3'A was increasingly pronounced in individuals infected with HIV-1 for longer periods, was twice as strong as the dominant genetic restriction of AIDS conferred by CCR5 and CCR2 chemokine receptor variants in these populations, and was complementary with these mutations in delaying the onset of AIDS.
Journal ArticleDOI
MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis
Jeffrey B. Kopp,Michael W. Smith,George W. Nelson,Randall C. Johnson,Barry I. Freedman,Donald W. Bowden,Taras K. Oleksyk,Louise M. McKenzie,Hiroshi Kajiyama,Tejinder S. Ahuja,Jeffrey S. Berns,William A. Briggs,Monique E. Cho,Richard A. Dart,Paul L. Kimmel,Stephen M. Korbet,Donna M. Michel,Michele H. Mokrzycki,Jeffrey R. Schelling,Eric E. Simon,Howard Trachtman,David Vlahov,Cheryl A. Winkler +22 more
TL;DR: Genetic variation at the MYH9 locus substantially explains the increased burden of FSGS and hypertensive ESKD among African Americans.