K
Kan Luk Cheung
Researcher at University of Southampton
Publications - 11
Citations - 700
Kan Luk Cheung is an academic researcher from University of Southampton. The author has contributed to research in topics: Chromosomal translocation & Fluorescence in situ hybridization. The author has an hindex of 11, co-authored 11 publications receiving 670 citations. Previous affiliations of Kan Luk Cheung include St Bartholomew's Hospital & Salisbury District Hospital.
Papers
More filters
Journal ArticleDOI
Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia
Anthony V. Moorman,Sue Richards,M Martineau,Kan Luk Cheung,Hazel M. Robinson,G. Reza Jalali,Zoë J. Broadfield,Rachel L. Harris,Kerry E. Taylor,Brenda Gibson,Ian Hann,Frank Hill,Sally E. Kinsey,Tim O B Eden,Chris Mitchell,Christine J. Harrison +15 more
TL;DR: It is confirmed that the outcome of children with HeH is heterogeneous and that specific trisomies can identify patients with the greatest and least risk of treatment failure.
Journal ArticleDOI
Deletion of chromosome 13 detected by conventional cytogenetics is a critical prognostic factor in myeloma
Laura Chiecchio,Rebecca K.M. Protheroe,A H Ibrahim,Kan Luk Cheung,C Rudduck,Gianpaolo Dagrada,E.D. Cabanas,T Parker,Mathew Nightingale,A Wechalekar,Kim Orchard,Christine J. Harrison,Nicholas C.P. Cross,Gareth J. Morgan,Fiona M. Ross +14 more
TL;DR: It is concluded that Δ13 detected by metaphase analysis is a critical prognostic factor in myeloma, and absence of Δ13, even in those patients yielding only normal or no metaphases, is associated with a relatively good prognosis.
Journal ArticleDOI
Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome
Hazel M. Robinson,Zoë J. Broadfield,Kan Luk Cheung,Louise Harewood,Rachel L. Harris,G R Jalali,M Martineau,Anthony V. Moorman,Kerry E. Taylor,Susan M. Richards,Chris Mitchell,Christine J. Harrison +11 more
TL;DR: Based on the stability of TCR gene rearrangements, a strategy for PCR target selection (TCRD+TAL1 TCRB TCRG) is proposed, which probably allows reliable minimal residual disease detection in all T-ALL patients.
Journal ArticleDOI
Frequent upregulation of MYC in plasma cell leukemia.
Laura Chiecchio,Gianpaolo Dagrada,Helen E. White,Mark R. Towsend,Rebecca K.M. Protheroe,Kan Luk Cheung,David M. Stockley,Kim Orchard,Kim Orchard,Nicholas C.P. Cross,Christine J. Harrison,Fiona M. Ross +11 more
TL;DR: It is concluded that MYC dysregulation by complex mechanisms is one of the major molecular events in the oncogenesis of PCL.
Journal ArticleDOI
Amplification of the ABL gene in T-cell acute lymphoblastic leukemia
Kerry E. Barber,M Martineau,Louise Harewood,Monica Stewart,Ewan R. Cameron,Jonathan C. Strefford,S Rutherford,T D Allen,Zoë J. Broadfield,Kan Luk Cheung,Rachel L. Harris,G R Jalali,Anthony V. Moorman,Hazel M. Robinson,Christine J. Harrison +14 more
TL;DR: Maturation and apoptosis of primary human acute myeloblastic leukemia cells are determined by TNF-alpha exclusively through CD120A stimulation as well as by two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies.