H
Hazel M. Robinson
Researcher at University of Southampton
Publications - 26
Citations - 1785
Hazel M. Robinson is an academic researcher from University of Southampton. The author has contributed to research in topics: Chromosome 21 & Fluorescence in situ hybridization. The author has an hindex of 16, co-authored 26 publications receiving 1649 citations.
Papers
More filters
Journal ArticleDOI
Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia
Yang Li,Claire Schwab,Sarra Ryan,Elli Papaemmanuil,Hazel M. Robinson,Patricia Jacobs,Anthony V. Moorman,Sara Dyer,Julian Borrow,Mike Griffiths,Nyla A. Heerema,Andrew J. Carroll,Polly Talley,Nick Bown,Nick Telford,Fiona M. Ross,Lorraine Gaunt,Richard J. Q. McNally,Bryan D. Young,Paul Sinclair,Vikki Rand,Manuel R. Teixeira,Olivia Joseph,Ben Robinson,Mark Maddison,Nicole Dastugue,Peter Vandenberghe,Claudia Haferlach,Philip J. Stephens,Jiqiu Cheng,Peter Van Loo,Peter Van Loo,Michael R. Stratton,Peter J. Campbell,Peter J. Campbell,Christine J. Harrison +35 more
TL;DR: It is shown that individuals born with the rare constitutional Robertsonian translocation between chromosomes 15 and 21, rob(15;21)(q10;q10)c, have approximately 2,700-fold increased risk of developing iAMP21 ALL compared to the general population.
Journal ArticleDOI
Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21)
Anthony V. Moorman,Susan M. Richards,Hazel M. Robinson,Jonathan C. Strefford,Brenda Gibson,Sally E. Kinsey,Tim Eden,Ajay Vora,Chris Mitchell,Christine J. Harrison +9 more
TL;DR: Patients with acute lymphoblastic leukemia and an intrachromosomal amplification of chromosome 21 (iAMP21) comprise a novel and distinct biological subgroup and have a significantly inferior event-free and overall survival at 5 years compared with other patients.
Journal ArticleDOI
Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia
Christine J. Harrison,Anthony V. Moorman,Zoë J. Broadfield,Kan L. Cheung,Rachel L. Harris,G. Reza Jalali,Hazel M. Robinson,Kerry E. Barber,Susan M. Richards,Chris Mitchell,Tim O B Eden,Ian Hann,Frank Hill,Sally E. Kinsey,Brenda Gibson,John S. Lilleyman,Ajay Vora,Anthony H. Goldstone,Ian M. Franklin,I. Jill Durrant,M Martineau +20 more
TL;DR: In this article, a study of children and adults with acute lymphoblastic leukaemia (ALL) is the largest series of patients with hypodiploidy (<46 chromosomes) yet reported.
Journal ArticleDOI
Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia
Anthony V. Moorman,Sue Richards,M Martineau,Kan Luk Cheung,Hazel M. Robinson,G. Reza Jalali,Zoë J. Broadfield,Rachel L. Harris,Kerry E. Taylor,Brenda Gibson,Ian Hann,Frank Hill,Sally E. Kinsey,Tim O B Eden,Chris Mitchell,Christine J. Harrison +15 more
TL;DR: It is confirmed that the outcome of children with HeH is heterogeneous and that specific trisomies can identify patients with the greatest and least risk of treatment failure.
Journal ArticleDOI
Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases.
Louise Harewood,Hazel M. Robinson,Rachel L. Harris,M. S. Jabbar Al-Obaidi,G R Jalali,M Martineau,Anthony V. Moorman,N. Sumption,Susan M. Richards,Chris Mitchell,Christine J. Harrison +10 more
TL;DR: This study identifies multiple copies of the AML1 gene on a duplicated chromosome 21, dup(21), as a recurrent abnormality in acute lymphoblastic leukemia (ALL), the largest report of this abnormality, permitting a detailed description of the variety of morphological forms that duplicated chromosomes 21 can assume.