Kana Otsubo

TL;DR: It is demonstrated that the Ubiquitin-coding gene UBA52 is not just an ubiquitin supplier to the ubiquit in pool but is also a regulator of the ribosomal protein complex.

TL;DR: Findings provide novel insights into how atypical polyubiquitin is recruited by SQSTM1/p62 and an inducible-PolyUb-FC system for visualizing chain-specific polyubanquitin.

TL;DR: It is suggested that HADHA is involved in long-chain fatty acid-induced autophagy in IECs, thus providing new insights into the pathology of IBD and revealing novel therapeutic targets of I BD.

TL;DR: It is demonstrated that the activation of necroptosis with TNF‐α plus the cell‐permeable pan‐caspase inhibitor Z‐VAD induces LC3‐II and LC3 puncta, markers of autophagosomes, via the receptor‐interacting protein kinase 3 (RIPK3) in intestinal epithelial cells, indicating that necroPTosis attenuates autophagic flux before the lysosome fusion step.

TL;DR: This article showed that nickel particle ingestion may worsen Crohn's disease by perturbing autophagic processes in the intestine, providing new insights into environmental factors in Crohn disease pathogenesis.