M
Mamoru Watanabe
Researcher at Tokyo Medical and Dental University
Publications - 688
Citations - 23437
Mamoru Watanabe is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Ulcerative colitis & Inflammatory bowel disease. The author has an hindex of 74, co-authored 649 publications receiving 20402 citations. Previous affiliations of Mamoru Watanabe include National Defense Medical College & Harvard University.
Papers
More filters
Journal ArticleDOI
Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5 + stem cell
Shiro Yui,Tetsuya Nakamura,Toshiro Sato,Toshiro Sato,Yasuhiro Nemoto,Tomohiro Mizutani,Xiu Zheng,Shizuko Ichinose,Takashi Nagaishi,Ryuichi Okamoto,Kiichiro Tsuchiya,Hans Clevers,Mamoru Watanabe +12 more
TL;DR: Methods for long-term expansion of colonic stem cells positive for leucine-rich repeat containing G protein-coupled receptor 5 (Lgr5+ cells) in culture are described, showing the feasibility of colon stem-cell therapy based on the in vitro expansion of a single adult Colonic stem cell.
Journal ArticleDOI
The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD With the European Crohn's and Colitis Organization: When to Start, When to Stop, Which Drug to Choose, and How to Predict Response
Geert R. D'Haens,Remo Panaccione,Peter D.R. Higgins,Severine Vermeire,Miquel A. Gassull,Yehuda Chowers,Stephen B. Hanauer,Hans H Herfarth,Daan W. Hommes,Michael A. Kamm,Michael A. Kamm,Robert Löfberg,A. Quary,Bruce E. Sands,Ajit Sood,G. Watermayer,Bret A. Lashner,Marc Lémann,Scott E. Plevy,Walter Reinisch,Stefan Schreiber,Corey A. Siegel,S. R. Targan,Mamoru Watanabe,Brian G. Feagan,William J. Sandborn,Jean-Frederic Colombel,Simon Travis +27 more
TL;DR: Preliminary evidence suggests that a substantial proportion of patients in clinical remission for >1 year, without signs of active inflammation can remain in remission after stopping treatment, and there are insufficient data to make recommendations on when to stop anti-TNF therapy.
Journal ArticleDOI
Evidence-based clinical practice guidelines for inflammatory bowel disease
Katsuyoshi Matsuoka,Taku Kobayashi,Fumiaki Ueno,Toshiyuki Matsui,Fumihito Hirai,Nagamu Inoue,Jun Kato,Kenji Kobayashi,Kiyonori Kobayashi,Kazutaka Koganei,Reiko Kunisaki,Satoshi Motoya,Masakazu Nagahori,Hiroshi Nakase,Fumio Omata,Masayuki Saruta,Toshiaki Watanabe,Toshiaki Tanaka,Takanori Kanai,Yoshinori Noguchi,Ken Ichi Takahashi,Kenji Watanabe,Toshifumi Hibi,Yasuo Suzuki,Mamoru Watanabe,Kentaro Sugano,Tooru Shimosegawa +26 more
TL;DR: This English version was produced and edited based on the existing updated guidelines for ulcerative colitis and Crohn’s disease in Japanese, developed with the basic concept of the Grading of Recommendations Assessment, Development, and Evaluation system.
Journal ArticleDOI
Damaged epithelia regenerated by bone marrow–derived cells in the human gastrointestinal tract
Ryuichi Okamoto,Tomoharu Yajima,Motomi Yamazaki,Takanori Kanai,Makio Mukai,Shinichiro Okamoto,Yasuo Ikeda,Toshifumi Hibi,Johji Inazawa,Mamoru Watanabe +9 more
TL;DR: It is shown that bone marrow cells can repopulate the epithelia of the human gastrointestinal tract and a potential clinical application of bone marrow–derived cells for repairing severely damaged epithelIA, not only in the gastrointestinal tract but also in other tissues.
Journal ArticleDOI
Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes
Mamoru Watanabe,Yoshitaka Ueno,Tomoharu Yajima,Yasushi Iwao,Masaharu Tsuchiya,Hiromichi Ishikawa,Sadakazu Aiso,Toshifumi Hibi,Hiromasa Ishii +8 more
TL;DR: It is suggested that human intestinal epithelial cells and epithelial goblet cells produce IL-7, and locally produced IL- 7 may serve as a potent regulatory factor for intestinal mucosal lymphocytes.