K
Kanakachari Mogilicherla
Researcher at University of Kentucky
Publications - 17
Citations - 634
Kanakachari Mogilicherla is an academic researcher from University of Kentucky. The author has contributed to research in topics: RNA interference & RNA silencing. The author has an hindex of 8, co-authored 12 publications receiving 433 citations. Previous affiliations of Kanakachari Mogilicherla include Indian Council of Agricultural Research.
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Journal ArticleDOI
Reduced stability and intracellular transport of dsRNA contribute to poor RNAi response in lepidopteran insects.
Jayendra Nath Shukla,Megha Kalsi,Amit Sethi,Kenneth E. Narva,Elane Fishilevich,Satnam Singh,Kanakachari Mogilicherla,Subba Reddy Palli +7 more
TL;DR: The data showed that the degradation and intracellular transport of dsRNA are the major factors responsible for reduced RNAi efficiency in lepidopteran insects.
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Comparative analysis of double-stranded RNA degradation and processing in insects.
Indrakant K. Singh,Indrakant K. Singh,Satnam Singh,Satnam Singh,Kanakachari Mogilicherla,Jayendra Nath Shukla,Jayendra Nath Shukla,Subba Reddy Palli +7 more
TL;DR: Data suggest that dsRNA digestion by dsRNases and its processing to siRNAs in the cells are among the major factors contributing to differential RNAi efficiency reported among insects.
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Double-stranded RNA binding protein, Staufen, is required for the initiation of RNAi in coleopteran insects.
June-Sun Yoon,Kanakachari Mogilicherla,Dhandapani Gurusamy,Xien Chen,Shankar C. R. R. Chereddy,Subba Reddy Palli +5 more
TL;DR: Experiments in two coleopteran insects showed the requirement of StaufenC for RNAi, especially for processing of double-stranded RNA (dsRNA) to small interfering RNA, which will help improve RNAi in noncoleoptera insects and manage RNAi resistance in colepteran insects.
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RNA interference in the Colorado potato beetle, Leptinotarsa decemlineata: Identification of key contributors.
June-Sun Yoon,Jayendra Nath Shukla,Zhong Jun Gong,Kanakachari Mogilicherla,Subba Reddy Palli +4 more
TL;DR: Results from Vha16 gene silencing and bafilomycin-A1 treatment suggest that endosomal escape plays an important role in dsRNA-mediated RNAi in Lepd-SL1 cells.
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Improving RNAi in the Brown Marmorated Stink Bug: Identification of target genes and reference genes for RT-qPCR
TL;DR: Feeding dsRNA causes target gene knockdown and mortality in BMSB, and 18S and 60S RP are identified as the best genes to use as a reference in reverse-transcriptase quantitative PCR (RT-qPCR).