Kangjian Qiao

TL;DR: Stable co-culture in the same bioreactor was achieved by designing a mutualistic relationship between the two species in which a metabolic intermediate produced by E. coli was used and functionalized by yeast.

TL;DR: Estimating the mechanistic details of the lipogenic phenotype, particularly the cellular compartmentalization of distinct metabolic pathways, fatty acid synthase structure, activating free fatty acids to acyl-CoAs, and decoupling nitrogen starvation from lipogenesis, allowed us to efficiently produce fatty acid ethyl esters, fatty alkanes, medium chain-length fatty acids, fatty alcohols, and triacylglycerides.

TL;DR: It is shown that redox engineering could enable commercialization of microbial carbohydrate-based lipid production via synthetic pathways converting glycolytic NADH into the lipid biosynthetic precursors NADPH or acetyl-CoA.

TL;DR: The development of a microbial catalyst with the highest reported lipid yield, titer and productivity to date is described, an important step towards the development of an efficient and cost-effective process for biodiesel production from renewable resources.

TL;DR: This study investigated cellular oxidative stress defense pathways in Yarrowia lipolytica to further improve the lipid titer, yield, and productivity and determined that coupling glutathione disulfide reductase and glucose‐6‐phosphate dehydrogenase along with aldehyde dehydrogenases are efficient solutions to combat reactive oxygen and alde Hyde stress in Y. lipolyTica.