K
Karen F. Kozarsky
Researcher at University of Pennsylvania
Publications - 5
Citations - 1777
Karen F. Kozarsky is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: LDL receptor & Genetic enhancement. The author has an hindex of 5, co-authored 5 publications receiving 1762 citations. Previous affiliations of Karen F. Kozarsky include University of Michigan.
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A model system for in vivo gene transfer into the central nervous system using an adenoviral vector.
TL;DR: A model system of direct gene transfer using a replication–defective adenoviral vector containing a β–galactosidase gene to transduce brain neurons is developed, suggesting an attractive and efficient alternative for neuronal gene transfer in vivo.
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Gene therapy: adenovirus vectors.
TL;DR: The fact that adenovirus infects most cell types with no requirement for cell division, combined with the high titers and high efficiency of gene transfer obtainable with recombinant adenOVirus, make it a promising system for in vivo human gene therapy.
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In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses.
Karen F. Kozarsky,D.R. McKinley,L.L. Austin,Steven E. Raper,L.D. Stratford-Perricaudet,James M. Wilson +5 more
TL;DR: These studies illustrate the advantages of recombinant adenoviruses for the treatment of liver metabolic diseases and define issues, such as viral genome instability and blocking immune response, that need to be overcome before the promise of this technology can be fully realized.
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Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene.
TL;DR: This work evaluated an alternative strategy of ectopic expression in the liver of the very low density lipoprotein (VLDL) receptor, which is homologous to the LDL receptor but has a different pattern of expression.
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Hepatic expression of the catalytic subunit of the apolipoprotein B mRNA editing enzyme (apobec-1) ameliorates hypercholesterolemia in LDL receptor-deficient rabbits.
Karen F. Kozarsky,Denise K. Bonen,Federico Giannoni,Toru Funahashi,James M. Wilson,Nicholas O. Davidson +5 more
TL;DR: Apolipoprotein (apo) B48, a protein contained in intestinally derived lipoprotein particles, is synthesized by post-transcriptional editing of apoB100 mRNA, which is mediated by an enzyme complex that includes the catalytic subunit, apobec-1.