K
Karen H. Hales
Researcher at Southern Illinois University Carbondale
Publications - 28
Citations - 2069
Karen H. Hales is an academic researcher from Southern Illinois University Carbondale. The author has contributed to research in topics: Steroidogenic acute regulatory protein & Mitochondrion. The author has an hindex of 18, co-authored 28 publications receiving 1957 citations. Previous affiliations of Karen H. Hales include University of Michigan & University of Illinois at Chicago.
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Journal ArticleDOI
Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis.
TL;DR: Examination of ROS on steroidogenic acute regulatory (StAR) protein in MA-10 cells and mitochondrial perturbation of the mitochondria and dissipation of Deltapsi(m) results in the inhibition of StAR protein expression and its import, processing, and cholesterol transfer activity.
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Mitochondrial processing of newly synthesized steroidogenic acute regulatory protein (StAR), but not total StAR, mediates cholesterol transfer to cytochrome P450 side chain cleavage enzyme in adrenal cells.
TL;DR: The present study of the activation of cholesterol metabolism by bromo-cAMP in adrenal cells in relation to35S-StAR turnover indicates that targeting of pp30 to the inner membrane provides the dominant cholesterol transport mechanism.
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Spatio-temporal expression patterns of steroidogenic acute regulatory protein (StAR) during follicular development in the rat ovary.
Tamar Ronen-Fuhrmann,Rina Timberg,Steven R. King,Karen H. Hales,Dale B. Hales,Douglas M. Stocco,Joseph Orly +6 more
TL;DR: These findings imply that, in immature rats undergoing hormonally induced first ovulation: 1) the early phases of follicular development are supported by androgen production originating from nonfollicular cells; 2) estrogen production in the granulosa cells of Graafian follicles is nourished by a submaximal androgenic output in the theca-interstitial compartments of the ovary.
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Transcriptional regulation of the rat steroidogenic acute regulatory protein gene by steroidogenic factor 1.
TL;DR: It is demonstrated that cAMP administration to rat luteal cells stimulates expression of both StAR messenger RNA and protein, and the two proximal SF-1 binding sites are crucial for StAR gene transcription, both at a basal level and in response to cAMP stimulation.
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Role of cytokines in testicular function.
TL;DR: The purpose of this review is to examine the role of cytokines in the regulation of steroidogenesis and spermatogenesis in the testis under physiological and pathophysiological conditions and considers clinical investigations that help to improve the evaluation and treatment of male infertility.