D
Dale B. Hales
Researcher at Southern Illinois University School of Medicine
Publications - 97
Citations - 6764
Dale B. Hales is an academic researcher from Southern Illinois University School of Medicine. The author has contributed to research in topics: Ovarian cancer & Steroidogenic acute regulatory protein. The author has an hindex of 41, co-authored 96 publications receiving 6291 citations. Previous affiliations of Dale B. Hales include University of Illinois at Urbana–Champaign & University of Michigan.
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Journal ArticleDOI
Overview of Steroidogenic Enzymes in the Pathway from Cholesterol to Active Steroid Hormones
Anita H. Payne,Dale B. Hales +1 more
TL;DR: This review presents a detailed description of the enzymes involved in the biosynthesis of active steroid hormones, with emphasis on the human and mouse enzymes and their expression in gonads, adrenal glands, and placenta.
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Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis.
TL;DR: Examination of ROS on steroidogenic acute regulatory (StAR) protein in MA-10 cells and mitochondrial perturbation of the mitochondria and dissipation of Deltapsi(m) results in the inhibition of StAR protein expression and its import, processing, and cholesterol transfer activity.
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Testicular macrophage modulation of Leydig cell steroidogenesis.
TL;DR: This review will highlight recent advances in the study of the immuno-endocrinology of the testis, in particular how macrophage-derived inflammatory mediators affect Leydig cell functions, and the beneficial and deleterious outcomes resulting from macrophages-Leydig cell interactions.
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Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into Leydig cell mitochondria
Thierry Hauet,Zhi-Xing Yao,Himangshu S. Bose,Christopher T. Wall,Zeqiu Han,Wenping Li,Dale B. Hales,Walter L. Miller,Martine Culty,Vassilios Papadopoulos +9 more
TL;DR: Reincorporation of in vitro transcribed/translated PBR, but not PBR missing the cholesterol-binding domain, into MA-10 mitochondria rescued the ability of the mitochondria to form steroids and the ability to respond to StAR and Tom/StAR proteins.
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Mitochondrial processing of newly synthesized steroidogenic acute regulatory protein (StAR), but not total StAR, mediates cholesterol transfer to cytochrome P450 side chain cleavage enzyme in adrenal cells.
TL;DR: The present study of the activation of cholesterol metabolism by bromo-cAMP in adrenal cells in relation to35S-StAR turnover indicates that targeting of pp30 to the inner membrane provides the dominant cholesterol transport mechanism.