K
Karen L. Valentino
Researcher at Pfizer
Publications - 4
Citations - 271
Karen L. Valentino is an academic researcher from Pfizer. The author has contributed to research in topics: Caspase 3 & Apoptosis. The author has an hindex of 2, co-authored 4 publications receiving 269 citations.
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Apoptosis of sinusoidal endothelial cells occurs during liver preservation injury by a caspase-dependent mechanism.
Shiho Natori,Markus Selzner,Karen L. Valentino,Lawrence C. Fritz,Anu Srinivasan,Pierre A. Clavien,Gregory J. Gores +6 more
TL;DR: During liver CI/WR injury: selective apoptosis of endothelial cells occurs; caspase 3 is activated only in endothelial Cells; and a casp enzyme inhibitor reduces endothelial cell apoptosis and prolongs animal survival after OLT, which could prove useful in clinical transplantation.
Journal Article
Characterization of the caspase inhibitor IDN-1965 in a model of apoptosis-associated liver injury.
Niel C. Hoglen,Brad P. Hirakawa,Craig D. Fisher,Suzanne Weeks,Anu Srinivasan,Angela M. Wong,Karen L. Valentino,Kevin J. Tomaselli,Xu Bai,Donald S. Karanewsky,Patricia C. Contreras +10 more
TL;DR: The broad-spectrum caspase inhibitor IDN-1965 is markedly effective at inhibiting Fas-mediated apoptosis by multiple routes of administration and appears promising for the treatment of apoptosis-mediated liver injury based on potency and postinsult efficacy.