Anu Srinivasan

TL;DR: In the presence of caspase‐3 the amount of active casp enzyme‐8 generated at the DISC determines whether a mitochondria‐independent apoptosis pathway is used (type I cells) or not (type II cells).

TL;DR: The existence of a time-dependent evolution of ischemic injury characterized by the close correspondence between caspase-like enzyme activation and an associated increase in immunoreactive product (caspases-3p20) beginning at or before reperfusion and followed several hours later by morphological and biochemical features of apoptosis is suggested.

TL;DR: In this paper, a positive correlation between the degree of neuronal loss in dopaminergic (DA) cell groups affected in the mesencephalon of Parkinson's disease patients and the percentage of caspase-3-positive neurons in these cell groups in control subjects was observed.

TL;DR: In this article, the activated form of caspase-3, the central effector enzyme of the apoptotic cascade, was detected in granules of granulovacuolar degeneration.

TL;DR: CM1 demonstrated an apparent specificity for activated caspase-3 by specifically immunolabeling only apoptotic but not necrotic cortical neurons in vitro and indicates that CM1 is a useful reagent for its in situ detection.