K
Karen Stein
Researcher at Merck & Co.
Publications - 181
Citations - 4057
Karen Stein is an academic researcher from Merck & Co.. The author has contributed to research in topics: Eating disorders & Pembrolizumab. The author has an hindex of 28, co-authored 181 publications receiving 3342 citations. Previous affiliations of Karen Stein include University of Michigan & Michigan State University.
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Journal ArticleDOI
T-Cell–Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028
Patrick A. Ott,Yung-Jue Bang,Sarina Anne Piha-Paul,Albiruni Ryan Abdul Razak,Jaafar Bennouna,Jean-Charles Soria,Hope S. Rugo,Roger B. Cohen,Bert H. O'Neil,Janice M. Mehnert,Juanita Lopez,Toshihiko Doi,Emilie M.J. van Brummelen,Razvan Cristescu,Ping Yang,Kenneth Emancipator,Karen Stein,Mark Ayers,Andrew K. Joe,Jared Lunceford +19 more
TL;DR: Response patterns indicate that patients with tumors that had high levels of both TMB and inflammatory markers (GEP or PD-L1) represent a population with the highest likelihood of response to pembrolizumab in multiple tumor types.
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Detecting navigational deficits in cognitive aging and Alzheimer disease using virtual reality
TL;DR: It is concluded that virtual navigation testing reveals deficits in aging and AD that are associated with potentially grave risks to patients and the community.
Journal ArticleDOI
Death anxiety: an analysis of an evolving concept.
Rebecca H. Lehto,Karen Stein +1 more
TL;DR: This article identifies defining attributes, antecedents, and consequences of the concept of death anxiety using Rodgers (2000) evolutionary method of concept analysis.
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Safety and antitumor activity of the anti–PD-1 antibody pembrolizumab in patients with advanced colorectal carcinoma
Bert H. O'Neil,John M. Wallmark,David Lorente,Elena Elez,Judith Raimbourg,Carlos Gomez-Roca,Samuel Ejadi,Sarina Anne Piha-Paul,Mark N. Stein,Albiruni Ryan Abdul Razak,Katia Dotti,Armando Santoro,Roger B. Cohen,M. Gould,Sanatan Saraf,Karen Stein,Sae-Won Han +16 more
TL;DR: Pembrolizumab demonstrated a favorable safety profile in advanced PD-L1–positive CRC, and antitumor activity was observed in a single patient with MSI-high CRC, warranting further evaluation in this patient population.
Journal Article
The contribution of vitamin K2 (menaquinones) produced by the intestinal microflora to human nutritional requirements for vitamin K.
TL;DR: Data provide direct evidence for the absorption of vitamin K2 from the distal small bowel, supporting a definite role for bacterially synthesized vitamin K1 in contributing to the human nutritional requirements of this vitamin.