K
Karin A. Stephenson
Researcher at McMaster University
Publications - 21
Citations - 1258
Karin A. Stephenson is an academic researcher from McMaster University. The author has contributed to research in topics: Peptide & Solid-phase synthesis. The author has an hindex of 11, co-authored 21 publications receiving 1191 citations.
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Journal ArticleDOI
The medicinal chemistry of carboranes
John F. Valliant,Katharina J. Guenther,Arienne S. King,Pierre Morel,Paul Schaffer,Oyebola O. Sogbein,Karin A. Stephenson +6 more
TL;DR: The medicinal chemistry of dicarba-closo-dodecaboranes (otherwise referred to as carboranes) has traditionally centered on their use in boron neutron capture therapy (BNCT) as mentioned in this paper.
Journal ArticleDOI
Bridging the gap between in vitro and in vivo imaging: isostructural Re and 99mTc complexes for correlating fluorescence and radioimaging studies.
Karin A. Stephenson,Sangeeta Ray Banerjee,Travis R. Besanger,Oyebola O. Sogbein,Murali K. Levadala,Nicole McFarlane,Jennifer A. Lemon,Douglas R. Boreham,Kevin P. Maresca,John D. Brennan,John W. Babich,Jon Zubieta,John F. Valliant +12 more
TL;DR: A bifunctional ligand that is capable of forming Re and 99mTc complexes as complementary fluorescent and radioactive probes was developed and was incorporated into fMLFG, a peptide that binds to the formyl peptide receptor (FPR).
Journal ArticleDOI
Bifunctional single amino acid chelates for labeling of biomolecules with the {Tc(CO)3}+ and {Re(CO)3}+ cores. Crystal and molecular structures of [ReBr(CO)3(H2NCH2 C5H4N)], [Re(CO)3{(C5H4 NCH2)2NH}]Br,
Sangeeta Ray Banerjee,Murali K. Levadala,Neva Lazarova,Lihui Wei,John F. Valliant,Karin A. Stephenson,John W. Babich,Kevin P. Maresca,Jon Zubieta +8 more
Journal ArticleDOI
A new strategy for the preparation of peptide-targeted radiopharmaceuticals based on an fmoc-lysine-derived single amino acid chelate (SAAC). automated solid-phase synthesis, NMR characterization, and in vitro screening of fMLF(SAAC)G and fMLF[(SAAC-Re(CO)3)+]G.
Karin A. Stephenson,Jon Zubieta,Sangeeta Ray Banerjee,Murali K. Levadala,Linda Taggart,Lorna A. Ryan,Nicole McFarlane,Douglas R. Boreham,Kevin P. Maresca,John W. Babich,John F. Valliant +10 more
TL;DR: The results of this work demonstrate the feasibility and numerous benefits of using the SAAC system to prepare peptide-targeted Tc (I) and Re(I) radiopharmaceuticals.
Journal ArticleDOI
Synthesis of Boroxifen, A Nido-Carborane Analogue of Tamoxifen
TL;DR: A nido-carborane analogue of tamoxifen, the widely employed breast cancer therapy agent, was prepared as an archetype of a potential new class of antiestrogen and boron neutron capture therapy agent in which the carborane is incorporated within the framework of the parent compound as discussed by the authors.