K
Karl-Heinz Enssle
Researcher at University of Perugia
Publications - 3
Citations - 452
Karl-Heinz Enssle is an academic researcher from University of Perugia. The author has contributed to research in topics: Cytokine & Interleukin 4. The author has an hindex of 3, co-authored 3 publications receiving 446 citations.
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Journal ArticleDOI
Th1 and Th2 cytokines in mice with invasive aspergillosis.
Elio Cenci,Stefano Perito,Karl-Heinz Enssle,Paolo Mosci,Jean-Paul Latgé,Luigina Romani,Francesco Bistoni +6 more
TL;DR: Findings indicate that in murine invasive aspergillosis, production of IL-4 by CD4+ T cells may be one major factor discriminating susceptibility and resistance to infection.
Journal ArticleDOI
T Helper Cell Type 1 (Th1)- and Th2-like Responses Are Present in Mice with Gastric Candidiasis but Protective Immunity Is Associated with Th1 Development
Elio Cenci,Antonella Mencacci,Roberta Spaccapelo,Laura Tonnetti,Paolo Mosci,Karl-Heinz Enssle,Paolo Puccetti,Luigina Romani,Francesco Bistoni +8 more
TL;DR: Activation of Th1- but not Th2-like responses may be responsible locally for controlling GI candidiasis and generating protective immunity.
Journal ArticleDOI
Cure of Murine Candidiasis by Recombinant Soluble Interleukin-4 Receptor
Paolo Puccetti,Antonella Mencacci,Elio Cenci,Roberta Spaccapelo,Paolo Mosci,Karl-Heinz Enssle,Luigina Romani,Francesco Bistoni +7 more
TL;DR: Following sIL-4R treatment, persistent ablation of circulating IL-4 detected by ELISA was associated with a cure rate of > 90% in otherwise lethally infected mice, onset of durable protection, and a shift from a predominant Th2 to a Th1 pattern of reactivity.