Karolin Isaksson

TL;DR: It is found that the co-occurrence of tumour-associated CD8 + T cells and CD20 + B cells, and the formation of tertiary lymphoid structures, are linked with improved survival in cohorts of patients with metastatic melanoma.

TL;DR: The multiregion tumor-sequencing approach highlights the genetic evolution and non-UVB mutational signatures associated with melanoma development and progression, and may provide a more comprehensive perspective of patient outcome.

TL;DR: Possible ways to prevent abdominal adhesions are discussed and an update is provided as comes to where the authors stand today in research regarding experimental and clinical use of various antiadhesive agents.

TL;DR: Hospitalization due to SBO, between open and laparoscopic procedures, in patients operated on because of suspected appendicitis demonstrated a significant difference, favoring the Laparoscopic approach.

TL;DR: It is confirmed in this cohort that PTEN alterations promote immune evasion highlighted by decreased frequency of T-cell infiltration in such tumors, resulting in a worse patient survival, and suggested that dedifferentiated PTEN negative melanoma tumors have poor patient outcome, no T- cell infiltration, and transcriptional properties rendering them resistant to targeted- and immuno-therapy.